Predictive Validity of the Personal and Social Performance Scale for PANSS Outcomes in Schizophrenia: a Severity-stratified Study
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 763
- 试验地点
- 1
- 主要终点
- the gender different in the effect of paliperidone treatment in schizophrenia
研究概览
简要总结
The Positive and Negative Syndrome Scale (PANSS) is a widely used instrument for assessing symptom severity in schizophrenia, whereas the Personal and Social Performance Scale (PSP) provides a practical measure of functional outcomes. This study aimed to evaluate the predictive validity of the PSP for PANSS outcomes in individuals with schizophrenia.
A total of 763 patients diagnosed with schizophrenia and receiving paliperidone treatment were recruited in a 12-week multicenter prospective study. Among participants with a baseline PANSS score greater than 90, those with a 12-week PSP score above 60 were more likely to achieve a reduction of more than 20% in PANSS scores, whereas those with a PSP score below 60 showed less improvement.
详细描述
This study employed a 12-week, multicenter, prospective research design focusing on the administration of the antipsychotic medication paliperidone. Assessments were conducted at baseline, week 4, and week 12. Two widely used scales-the PANSS and PSP-were utilized to evaluate patients before and after treatment, followed by a correlation analysis of the results.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •criteria diagnosis of schizophrenia
排除标准
- •schizoaffective disorder
- •severe major depressive disorder
- •bipolar disorder
- •substance use disorders
- •organic brain conditions
研究组 & 干预措施
The Effects of paliperidone on symptom improvement in schizophrenia
Patients diagnosed with schizophrenia and receiving paliperidone treatment were recruited in a 12-week multicenter prospective study. Among participants with a baseline PANSS score greater than 90, those with a 12-week PSP score above 60 were more likely to achieve a reduction of more than 20% in PANSS scores, whereas those with a PSP score below 60 showed less improvement.
干预措施: This study employed a 12-week, multicenter, prospective research design focusing on the administration of the antipsychotic medication paliperidone. (Drug)
结局指标
主要结局
the gender different in the effect of paliperidone treatment in schizophrenia
时间窗: The differences were evaluated before treatment, and week 4 and week 12 after treatment.
The difference of paliperidone treatment between males and females were explored at baseline, week 4, and week 12.
次要结局
- The PANSS responses in schizophrenia with paliperidone(The responses of PANSS were evaluated before the treatment, and week 4 and week 12 after treatment)
研究者
For-Wey Lung
Professor
Calo Psychiatric Center