Variation of Genes Controlling Carbohydrate and Lipid Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 2,050
- 试验地点
- 1
- 主要终点
- Skeletal muscle insulin sensitivity
研究概览
简要总结
Aim of the study is to investigate genes regulating glucose and lipid metabolism in subjects whose glucose metabolism, lipid metabolism, blood flow, or body fat distribution has been measured using positron emission tomography (PET), magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS) or computed tomography (CT) as part of their previous participation in clinical trials conducted at Turku PET Centre.
By combining information from PET, MRI, CT, proteomics, metabolomics and genetics analyses we aim to find connection between genetic variation and metabolic and cardiovascular disease.
详细描述
The data is collected as a separate part of the clinical imaging study protocols using a separate inform consent approved by the local ethics committee. The participation for this study consists of drawing whole blood, serum and plasma samples for genetics, proteomics and metabolomics analyses. The results from these studies are combined with baseline data from the original clinical imaging studies to find connections between genetic variation, metabolism, blood flow and body fat distribution in a cross-sectional setting.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Previous participation of studies measuring glucose metabolism, lipid metabolism, bloow flow and adiposity at Turku PET Centre
排除标准
- 未提供
结局指标
主要结局
Skeletal muscle insulin sensitivity
时间窗: Baseline
Skeletal muscle glucose uptake during euglycemic-hyperinsulinemic clamp (µmol/kg tissue/min)
次要结局
- Liver insulin sensitivity to glucose uptake(Baseline)
- Abdominal subcutaneous adipose tissue mass(Baseline)
- Myocardial fatty acid uptake(Baseline)
- Brown adipose tissue glucose uptake during cold exposure(Baseline)
- Abdominal subcutaneous adipose tissue insulin sensitivity to glucose uptake(Baseline)
- Liver fat content(Baseline)
- Abdominal subcutaneous adipose tissue fatty acid uptake(Baseline)
- Brown adipose tissue fatty acid uptake at fasting state(Baseline)
- Visceral adipose tissue fatty acid uptake(Baseline)
- Insulin sensitivity of adipose tissue lipolysis(Baseline)
- Myocardial insulin sensitivity(Baseline)
- Endogenous glucose production(Baseline)
- Visceral adipose tissue mass(Baseline)
- Brain insulin sensitivity to glucose uptake(Baseline)
- Liver fatty acid uptake(Baseline)
- Whole body insulin sensitivity(Baseline)
- Visceral adipose tissue insulin sensitivity to glucose uptake(Baseline)
- Brown adipose tissue insulin sensitivity(Baseline)
- Brown adipose tissue fatty acid uptake during cold exposure(Baseline)
- Skeletal muscle fatty acid uptake(Baseline)
- Coronary flow reserve(Baseline)
研究者
Pirjo Nuutila
Professor, chief physician
Turku University Hospital