NCT04455477Unknown不适用
Hemodynamic Effects of Nesiritide on Congestive Heart Failure Patients Receiving Mechanical Ventilation: A Prospective Observational Study
Shanghai Zhongshan Hospital1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2020年5月14日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Changes of cardiac output
研究概览
简要总结
The congestive heart failure is a common disease among patients who receive cardiac surgery and may lead to prolonged ventilation support. Nesiritide was a potential therapy for congestive heart failure. This study aimed to compare the Nesiritide induced hemodynamical status changes among congestive heart failure patients with invasive ventilation support.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age≥18 years；
- •Congestive Heart Failure;
- •With mechanical ventilation；
- •With hemodynamic monitoring devices;
- •The physicians made the decision of using Nesiritide.
排除标准
- •Unstable hemodynamic status；
- •Severe renal dysfunction.
结局指标
主要结局
Changes of cardiac output
时间窗: Before and 30-min after using a standard dose of Nesiritide
Changes of cardiac output measured by hemodynamical monitoring tools
Changes of systemic filling pressure
时间窗: Before and 30-min after using a standard dose of Nesiritide
Changes of the intercept of regression line of paired VR-RAP points at different PEEP levels.
次要结局
- Changes of cardiac function curve(Before and 30-min after using a standard dose of Nesiritide)
- Changes of venous return curve(Before and 30-min after using a standard dose of Nesiritide)
研究者
研究点 (1)
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