The Role of Nutrition in Muscle Function of Bariatric Surgery Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Change in weight
研究概览
简要总结
Current recommendations for protein intake after bariatric surgery are not based on strong scientific evidence. It remains unclear how much protein should be eaten to minimize muscle loss and preserve the metabolism and function of individuals post-bariatric surgery.
The objective of this study is to analyze the relationships between changes in body composition, nutrition and protein intake, and muscle function after bariatric surgery to further our understanding of the nutritional needs of patients after bariatric surgery.
We intend to recruit around 75 participants, men and women, aged between 18 and 65 years. Participants will be recruited from the Bariatric Surgery Clinic, McGill University Health Center.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and female
- •Aged 18 to 65 years old
- •Undergoing first bariatric surgery (any type)
- •Diabetics and non-diabetics
- •Non-smokers and non-cannabis consumers
排除标准
- •Pregnant and breastfeeding women
- •Individuals undergoing second bariatric surgery
- •Regular smokers and cannabis consumers
- •Current use of Ozempic (or Ozempic-like medication) and anti-psychotic meds
- •Limited physical mobility (using walking aids such as canes, walkers, or wheelchairs) and issues with hand resistance
- •Kidney disease, non-controlled / unstable hypertension and hypothyroidism, and any metabolic disease other than diabetes
结局指标
主要结局
Change in weight
时间窗: Baseline (pre-operation), and at 3-months and 6-months post-operation.
Overall weight loss (kg)
Change in BMI
时间窗: Baseline (pre-operation), and at 3-months and 6-months post-operation.
Height and weight will be measured and combined to report BMI (kg/m\^2).
Change in fat mass
时间窗: Baseline (pre-operation), and at 3-months and 6-months post-operation.
Body composition is measured by dual-energy x-ray absorptiometry.
Change in overall body fat percentage
时间窗: Baseline (pre-operation), and at 3-months and 6-months post-operation.
Body composition is measured by dual-energy x-ray absorptiometry.
Resting Energy Expenditure
时间窗: Baseline (pre-operation), and at 3-months and 6-months post-operation.
Resting energy expenditure will be measured in a fasted state by indirect calorimetry. The volume of oxygen and carbon dioxide and water vapor pressure will be taken into consideration to calculate the resting energy expenditure.
Substrate Oxidation
时间窗: Baseline (pre-operation), and at 3-months and 6-months post-operation.
Substrate oxidation will be measured in a fasted state by indirect calorimetry. The volume of oxygen, carbon dioxide, and water vapor pressure will be taken into consideration to calculate the respiratory exchange ratio.
Nurition and Protein Intake
时间窗: Baseline (pre-operation), and at 3-months and 6-months post-operation.
A 3-day food journal and a 24-hour food recall will measure the nutritional profile (protein intake). A 24-hour urine sample will be used to measure urinary nitrogen concentration.
Hormone and Inflammatory Marker Assays
时间窗: Baseline (pre-operation), and at 3-months and 6-months post-operation.
The inflammatory cytokines, chemokines, and adipokines in blood will be measured using Enzyme-Linked Immunosorbent Assay (ELISA).
次要结局
未报告次要终点
研究者
Sylvia Santosa
Professor
Concordia University, Montreal