Effect of Isometric Hand Grip Training on Blood Pressure of Hypertensive Patients With Obstructive Sleep Apnea
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Change at ambulatory blood pressure monitoring
研究概览
简要总结
Obstructive sleep apnea (OSA) is a common clinical condition, involving the development of arterial hypertension. A Meta analysis study have shown that isometric hand grip training promotes blood pressure reduction. It is going to be conducted a clinical trail to determine the effects of hand grip training in OSA patients to change the arterial hypertension.
详细描述
Background: obstructive sleep apnea (OSA) is a common clinical condition, involving the development of arterial hypertension. Meta analysis study have shown that isometric hand grip strength promotes blood pressure reduction, and its reduction is higher than that observed after aerobic training. Objective: to analyze the effects of the isometric hand grip on blood pressure changes of patients with uncontrolled arterial hypertension with OSA. Methods: a randomized controlled trial involving 18 adults with OSA and uncontrolled arterial hypertension of both sexes, randomized between control group (receive general guidelines) and hand grip group. 12 weeks of training with load equivalent to 30% of maximum voluntary capacity was performed. All participants will be submitted for evaluation of blood pressure (BP) central and brachial, pulse wave velocity, full polysomnography,before and after the study protocol (the change from the baseline at 12 weeks). Expected results: the authors believe that hand grip training can change (reduce) blood pressure in patient with OSA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •OSA diagnose based on polysomnography,
- •Apnea-Hypopnea Index (AHI) > 5,
- •arterial hypertension (systolic arterial pressure > 140 mmHg or diastolic arterial pressure > 90 mmHg)
排除标准
- •other heart disease
研究组 & 干预措施
Control group
Verbal informations about the disease, and exercise behavior, and nutrition.
干预措施: Control (Other)
Hand grip group
Three supervised sessions por week: 4 series (2 at each arm) of two minutes of isometric hand grip contraction at 30% of maximal voluntary contraction. Between series there will be two minutes to rest.
干预措施: Hand grip isometric contraction (Other)
结局指标
主要结局
Change at ambulatory blood pressure monitoring
时间窗: Change from the baseline ambulatory blood pressure monitoring at 12 weeks
24h of monitoring blood pressure
次要结局
- Chance at Apnea-Hypopnea Index (AHI)(Change from the baseline AHI at 12 weeks)
- Change at Pulse wave velocity(Change from the baseline pulse wave velocity at 12 weeks)
- Change at blood pressure(Change from the baseline brachial blood pressure at 12 weeks)
研究者
Rodrigo Pinto Pedrosa
Head of sleep laboratory and heart emergency room of Pernambuco , Principal Investigator.
University of Pernambuco