Multicenter Retrospective Cohort Study of Ivermectin as a SARS-CoV-2 Pre-exposure Prophylactic Method in Healthcare Workers in Dominican Republic
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 713
- 试验地点
- 2
- 主要终点
- Number of participants RT-PCR positive for Covid-19
研究概览
简要总结
This observational study, a multicenter retrospective cohort database study, carried out in two medical centers, Centro Medico Bournigal (CMBO) in Puerto Plata and Centro Medico Punta Cana (CMPC) in Punta Cana, Dominican Republic, sought to determine whether Ivermectin, at a weekly orally dose of 0.2 mg/kg, is an effective pre-exposure prophylactic method (PrEP) for the spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), in the healthcare workers. The study began on June 29, 2020 and ended on July 26, 2020 (4 weeks).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Active workers from Centro Medico Bournigal (CMBO) and Centro Medico Punta Cana (CMPC) during the study.
- •Exclusion Criteria
- •Workers with positive Covid-19 RT-PCR prior to the start of the study
- •Those that did not take the first dose of Ivermectin the first week at the start of the study
- •Those that did not complied with at least 2 out of 4 weekly doses
- •Those that had greater than 14 days difference in days between two intakes Ivermectin
排除标准
- 未提供
研究组 & 干预措施
Ivermectin Group
Healthcare personnel receiving Ivermectin weekly PrEP
干预措施: Ivermectin 6 Mg Oral Tablet (Drug)
结局指标
主要结局
Number of participants RT-PCR positive for Covid-19
时间窗: 4 weeks
Workers confirmed Covid-19 through Reverse Transcription Polymerase Chain Reaction (RT-PCR) test
次要结局
- Number of sick participants who condition deteriorated(4 weeks)
- Number of sick participants who died(4 weeks)