NCT05401721已完成不适用
Serum Copeptin in Cirrhotic Patients With Spontaneous Bacterial Peritonitis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 89
- 试验地点
- 1
- 主要终点
- compare serum levels of copeptin in cirrhotic patients with and without SBP
研究概览
简要总结
Current reports have demonstrated that copeptin predicts disease progression and prognosis in cirrhotic patients, independent of liver-specific scoring systems. To the best of our knowledge, few studies have addressed the association between copeptin and sepsis in cirrhotic patients, however, they were performed on different types of infections. Therefore, we will conduct this study with a focus on it is possible role in patients with SBP.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The diagnosis of liver cirrhosis will be based on clinical data and findings on abdominal ultrasound. The diagnosis of SBP will be based on the presence of at least 250 cells/ml PMNLs in the ascitic fluid, with or without positive ascitic fluid culture in the absence of hemorrhagic ascites and secondary peritonitis
排除标准
- •Patients with heart failure, coronary insufficiency, advanced chronic respiratory disease, polyuria-polydipsia syndrome and hypotension or shock.
- •Patients with chronic kidney disease treated with hemodialysis before admission.
- •Patients with previous liver or kidney transplantation.
- •Patients with intraabdominal malignancy.
- •Patients with severe infection other than SBP.
- •Patients who had received antibiotics before hospital admission.
结局指标
主要结局
compare serum levels of copeptin in cirrhotic patients with and without SBP
时间窗: 6 months
compare serum levels of copeptin in cirrhotic patients with and without SBP
次要结局
- assess serum copeptin levels in different stages of cirrhosis and its relationship with kidney and circulatory function(6 months)
研究者
Ahmed Abudeif Abdelaal, MD
Principal investigator
Sohag University
研究点 (1)
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