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临床试验/NCT00852514
NCT00852514已完成4 期

The Optimization of Blood Pressure and Fluid Status Control With Eight-Polar Bioelectrical Impedance Analysis

Taipei Veterans General Hospital, Taiwan2 个研究点 分布在 1 个国家目标入组 132 人开始时间: 2006年9月最近更新:
适应症

试验速览

阶段
4 期
状态
已完成
入组人数
132
试验地点
2
主要终点
systolic blood pressure

研究概览

简要总结

Peritoneal dialysis (PD) is a widely used modality of renal replacement therapy. Due to its continuous nature of therapy, better control of fluid status and preservation of residual renal function were presumed by most nephrologists. However, recent evidences showed that it might not be the case. The severity of fluid overloading and the need for anti-hypertensive agents to control blood pressure seems to be more severe for PD patients. Therefore, more aggressive strategy to control dry weight is mandatory in PD patients. However, over reduction of dry weight might affect residual renal function (RRF) and, probably, the survival of PD patients. A balance between reduction of dry weight and preservation of RRF is crucial for the care of PD patients. Currently, only clinical measures like cardiothoracic ratio on chest X-ray and absence of pedal edema were used to evaluate PD patient's dry weight. There is no objective method to determine dry weight accurately. In this prospective and randomized study, the investigators will use multi-frequency bio-impedance (MF-BIA) to detect intracellular and extracellular water (ECW) content of patients.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • age 18 to 80

排除标准

  • type I DM
  • Severe heart failure
  • unstable angina

结局指标

主要结局

systolic blood pressure

时间窗: one year

次要结局

未报告次要终点

研究者

申办方类型
Other Gov

研究点 (2)

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