Role of Magnetic Resonance Imaging and Ultrasonography in Evaluation of Muscle Diseases
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 36
- 主要终点
- Percentage of abnormal ultrasound and Magnetic resonance studies separately
研究概览
简要总结
This study aims to determine the association between the pathological changes detected by ultrasound and those detected in MRI in muscle diseases of different etiologies.
详细描述
Enrolled patients will be subjected to the following:
Neuro-imaging Studies:
- Skeletal Muscle ultrasound:
The muscle group(s) to be assessed will be determined based on the category of the muscle disease for which the patient is being evaluated. A linear probe of 5-12 megahertz will be used. 2. MRI of the suspected (affected) muscle group by ultrasound. Image acquisition: Selective regional MRI imaging will be done based on the results of muscle ultrasound MRI cuts included are the axial section of conventional T1- and T2-weighted sequences, for the evaluation of muscles' signal intensity and bulk.
Patients will be subjected to both imaging studies to compare their accuracy.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 4 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A clinical diagnosis of muscle diseases; irrespective of different etiologies
- •Age > 3 years
排除标准
- •Patients with altered muscle anatomy due to severe trauma, tumor or surgery.
- •Severe deformity preventing examination.
- •Age < 3years.
- •Patients with contraindications to MRI as patients with pacemaker, aneurysmal clipping, retained metallic
结局指标
主要结局
Percentage of abnormal ultrasound and Magnetic resonance studies separately
时间窗: through study completion, an average of 1 year
Abnormal Magnetic resonance study: muscle fat replacement (qualitatively through T1 weighted images, and qualitatively through Mercuric visual grading system), edema ( T2 relaxation time mapping), fibrosis ( magnetic resonance elastography) Abnormal muscle ultrasound study (replacement of healthy muscle with fat and fibrosis, manifested by an increase in echogenicity, visual method based on evaluating echogenicity in relation to other structures and semi-quantitatively)
Association between the results of Skeletal muscle ultrasound (normal vs. abnormal) and the results of MRI (normal vs. abnormal study)
时间窗: within 6 months after recruitment ends (Recruitment completion is anticipated In Sep 2023)
Association between the individual abnormalities detected by skeletal muscle ultrasound and those detected by MRI.
时间窗: within 6 months after recruitment ends (Recruitment completion is anticipated In Sep 2023)
Diagnostic accuracy of each modality in reference to the clinical and neurophysiological diagnosis and muscle biopsy.
时间窗: within 6 months after recruitment ends (Recruitment completion is anticipated In Sep 2023)
次要结局
未报告次要终点
研究者
Tayseer Mohamed Hashem Hamza
Resident doctor at assiut university
Assiut University