The Oral Microbiota in Autoimmune Thyroiditis is Distinctive And Predictive
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Transcriptional changes in oral microbiota
研究概览
简要总结
Autoimmune thyroiditis (AITD) mainly includes Hashimoto's thyroiditis (HT) and Grave's disease (GD). Studies have shown that autoimmune thyroiditis is closely related to microbial disorders such as autoimmune thyroiditis However, there is no report on the relationship between oral microecology and autoimmune thyroiditis. Therefore, our group will study the correlation between oral microbiota and AITD.
详细描述
Autoimmune thyroiditis (AITD) mainly includes Hashimoto's thyroiditis (HT) and Grave's disease (GD). Studies have shown that autoimmune thyroiditis is closely related to microbiological disorders. Intestinal microelements Both ecology and oral microecology belong to the category of microorganisms. It has been reported in the literature that intestinal microecology occurs disorder of autoimmune thyroiditis. However, there is no report on the correlation between oral microecology and autoimmune thyroiditis. When oral microbe flora When the immune system is disrupted, the immune balance is broken, the immune system is over-active, and the autoimmune disease (AID) is lost to the autoantigens and non-pathogenic commensal microbial flora antigens, including rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematosus, inflammatory bowel disease, and allergic diseases. However, the association between oral microbial flora and AITD remains unclear. . Therefore, the research group will carry out the correlation between oral microbial flora and AITD.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 18 to 65 years
- •GD was clinical diagnosed and thyroid function returned to normal
- •HT was clinical diagnosed and thyroid function is normal.
排除标准
- •Pregnancy
- •Lactation
- •Cigarette smoking
- •Alcohol addiction
- •Hypertension
- •Diabetes mellitus
- •Lipid dysregulation
- •BMI > 27
- •Recent (< 3 months prior) use of antibiotics, probiotics, prebiotics, symbiotics, hormonal medication, laxatives, proton pump inhibitors, insulin sensitizers or Chinese herbal medicine
- •History of disease with an autoimmune component, such as MS, rheumatoid arthritis, IBS, or IBD
- •History of malignancy or any gastrointestinal tract surgery
研究组 & 干预措施
Drug treatment group
30 GD patients who received treatment with Methimazole Pill or propylthiouracil pill
干预措施: Methimazole Pill (Drug)
Drug treatment group
30 GD patients who received treatment with Methimazole Pill or propylthiouracil pill
干预措施: Propylthiouracil Pill (Drug)
结局指标
主要结局
Transcriptional changes in oral microbiota
时间窗: Baseline, 3 months, 6 months, 9 months, 12 months
The microbiota measured by 16S rRNA gene
次要结局
- Serum thyroid function changed(Baseline, 3 months, 6 months, 9 months, 12 months)
