Short-term Immobilization and Rehabilitation of the Lower Limb: Changes in Strength, Size, and Neuromuscular Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Muscular size
研究概览
简要总结
The purpose of this study is to determine the effects of one week of knee-joint immobilization on muscle size, strength, neuromuscular function, and brain function. In addition, the effects of two different interventions (i.e., neuromuscular electrical stimulation and action observation/mental imagery) throughout immobilization will be determined. Following the immobilization period, participants that have lost strength will be rehabilitated with twice weekly resistance training sessions, and sex-based differences in rehabilitation timelines will be examined.
详细描述
This study will utilize a repeated measures design in healthy adults aged 18-40 years. After a thorough familiarization visit, muscular size, strength, neuromuscular responses, and corticospinal excitability/inhibition will be measured before (PRE) and after (POST) one week of unilateral knee joint immobilization of the left leg. Four groups will be examined: 1) immobilization only, 2) immobilization + daily neuromuscular electrical stimulation, 3) immobilization + daily action observation/mental imagery training, 4) a control group. Throughout the immobilization period, participants will be in a leg brace locked at 90 degrees knee flexion. They will perform daily range of motion exercises and wear a compression sock at all times to mitigate the risk of blood clots. Following completion of the immobilization period, participants that have lost strength will complete a supervised rehabilitation program of twice weekly lower body resistance training sessions until they have returned to baseline levels of strength. Group assignment will be randomized and blocked on sex to ensure an equal number of participants within each group consisting of a relatively equal number of males and females.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women between the ages of 18-40 years
- •Body mass index >20 kg/m2 or < 35 kg/m2
排除标准
- •Body mass index <20 kg/m2 or > 35 c
- •Experience of major joint pain/discomfort of the upper or lower limbs, back, or neck within the previous six months.
- •History of major musculoskeletal injury or surgery
- •Neuromuscular disease (e.g., Parkinson's, MS, ALS)
- •Metabolic disease (e.g., diabetes, thyroid disorder, metabolic syndrome)
- •Personal or family history of blood clots
- •Trouble using or controlling one's muscles
- •History of cancer
- •History of stroke
- •History of heart attack
- •History of arthritis
- •Use of an assistive walking device or mobility aids within the past six months
- •Use of anabolic steroids within the past six months
- •History of convulsions, seizures, or syncope
- •History of concussion as diagnosed by a physician
- •Certain medications (e.g., muscle relaxants, benzodiazepines)
- •Very thick hair or certain hairstyles that would impede the TMS coil from making direct contact with the scalp
- •Allergy to rubbing alcohol
- •Lack of transportation to and from the laboratory
- •Implant of any kind
- •Pregnancy
- •Allergy to silver
- •Diagnosis of any psychiatric condition
结局指标
主要结局
Muscular size
时间窗: 10 minutes
Changes in muscular size will be measured via ultrasonography of the quadriceps
Voluntary activation
时间窗: 15 minutes
Voluntary activation will be measured using the interpolated twitch technique
Rate of recovery
时间窗: 1.5 hours per session
The time taken to recover strength lost will be measured via number of resistance training sessions needed after immobilization
Muscular strength
时间窗: 15 minutes
Changes in muscular strength will be measured via maximal voluntary contraction torque
Corticospinal responses
时间窗: 30 minutes
Corticospinal responses will be measured with transcranial magnetic stimulation targeting the lower limbs
Motor unit behavior
时间窗: 10 minutes
Motor unit recruitment threshold and firing rate will be measured with surface electromyography signals detected from the quadriceps
次要结局
- Compliance(one week)
- Physical activity (Step count)(one week)
研究者
Matt Stock
Associate Professor of Physical Therapy
University of Central Florida