Role of Sensory Working Memory in Speech Motor Learning Aim 2
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Sensory Memory
研究概览
简要总结
The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal cortex associated with somatic and auditory working memory (Brodmann area 46v) to test its involvement in learning.
详细描述
This study will assess the relationship between sensory working memory and speech motor adaptation using a between subjects design. Participants will be assigned to one of two groups. Each group will undergo both auditory and somatosensory working memory tests. This will be followed by adaptation to altered auditory feedback. Using a different group of subjects, cTBS will be used to disrupt neural activity in Brodmann area 46v in ventrolateral prefrontal cortex to test its involvement in adaptation. One set of tests will focus on the effects of cTBS on both auditory and somatosensory working memory. A second set of tests will focus on the effects of cTBS on speech motor adaptation to altered auditory feedback. Both working memory and adaptation are assessed on 0 to 100 scales.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •right handed adults
- •no known physical or neurological abnormalities
排除标准
- •patients with:
- •cardiac pacemaker
- •surgical clips or values on the heart
- •metal or metallic fragments in any part of the body
- •pregnancy
- •claustrophobia
- •a personal or family history of epilepsy
- •currently taking antipsychotic drugs
- •currently taking antidepressant drugs
- •currently taking antianxiety drugs
- •history of concussion.
研究组 & 干预措施
Sensory Memory + cTBS to 46v
Sensory Memory + cTBS to 46v
干预措施: cTBS (Other)
Sensory Memory + cTBS to 46v
Sensory Memory + cTBS to 46v
干预措施: Adaptation (Behavioral)
Adaptation to Altered Auditory Feedback
Adaptation to Altered Auditory Feedback
干预措施: Adaptation (Behavioral)
Auditory Sensory Memory
Auditory Sensory Memory
干预措施: Adaptation (Behavioral)
Somatosensory Sensory Memory
Somatosensory Sensory Memory
干预措施: Adaptation (Behavioral)
Adaptation to Altered Auditory Feedback + cTBS to 46v
Adaptation to Altered Auditory Feedback + cTBS to 46v
干预措施: Adaptation (Behavioral)
Adaptation to Altered Auditory Feedback + cTBS to 46v
Adaptation to Altered Auditory Feedback + cTBS to 46v
干预措施: cTBS (Other)
结局指标
主要结局
Sensory Memory
时间窗: Single day experiment
Sensory Memory is measured on a 0 to 100 scale. A score of 100 corresponds to perfect memory.
Speech Motor Learning
时间窗: Performance as measured at the end of learning (single day experiment)
Learning is assessed on a 0 to 100 scale as change in speech sounds (speech formant frequencies). A score of 100 corresponds to complete adaptation.
次要结局
未报告次要终点