NCT00746044已完成不适用
Evaluation of the Ratio of Urinary Coproporphyrins I and III as a Potential Biomarker of MRP2 Function in Man
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Urinary coproporphyrins (I/I+III)ratio
研究概览
简要总结
Human Multidrug Related Protein 2 (MRP2) excretes several drugs and could therefore modulate their elimination. Individual's MRP2 activity is under genetic control. Thus it would be very useful to get an easily measurable biomarker reflecting individual's MRP2 activity. We aimed to investigate the ratio of urinary coproporphyrins I and III (UCP(I/I+III), known to be increased in patients with mutations in MRP2/ABCC2 gene.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Affiliated to an health insurance
排除标准
- •Patient not able to understand or to comply to the protocol
结局指标
主要结局
Urinary coproporphyrins (I/I+III)ratio
时间窗: End of three 24-hours periods
次要结局
- ABCC2 polymorphisms(At the time of entering in the study)
研究者
研究点 (1)
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