NCT00728104撤回不适用
Co-Enzyme Q10, L-Carnitine and Amitriptyline Usage in Cyclic Vomiting Syndrome (CVS): A Research Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- How two vitamin supplements are being used to treat cyclic vomiting syndrome
研究概览
简要总结
This is a study with the principle goal being to learn about the use of L-Carnitine and CoQ10, two vitamin supplements that are currently being used to treat Cyclic Vomiting Syndrome, largely initiated by parents. We want to learn how effective these supplements are compared to standard treatment, at what dose, and what onset of action in order to initiate future prospective study on these supplements.
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •3 discrete episodes of vomiting
- •normal health between episodes
- •stereotypical clinical pattern
- •no abnormal test results to account for vomiting (see exclusion criteria)
排除标准
- •abnormal UGI with small bowel follow-through revealing an anatomic anomaly, inflammatory or obstructive
- •Significantly abnormal endoscopic biopsies (moderate to severe esophagitis, H. pylori)
- •Abnormal abdominal ultrasound revealing hydronephrosis, cholelithiasis, pancreatitis
- •Positive screening for endocrine disorder (diabetic ketoacidosis, Addison's)
- •Positive screening for inborn errors of metabolism (hypoglycemia, lactic acidosis, hyperammonemia, organic acidemia, amino aciduria, elevated beta-ALA, porphobilinogen)
结局指标
主要结局
How two vitamin supplements are being used to treat cyclic vomiting syndrome
时间窗: Two years
次要结局
- How effective these supplements appear to be compared to standard treatment(Two years)
研究者
B Li
Professor of Pediatrics, MD
Medical College of Wisconsin
研究点 (1)
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