An Attempt at Translating Novelty-enhanced Extinction of Context Conditioning From Rodents to Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Physiological arousal response during reinstatement.
研究概览
简要总结
In rodents, novel exploration has been used to strengthen the consolidation of a variety of hippocampal-dependent learning tasks. To our knowledge, no attempt have been made to translate the effect of strengthening the memory of an extinction of a context conditioning memory. This study uses virtual reality for both context conditioning and novel exploration in an attempt at translating these findings from rodents to humans, thus, using novel exploration to strengthen an extinction memory. Threat responses are measured with skin conductance and startle responses. If this effect could be shown experimentally in humans, that experimental setup could become an important tool in understanding important memory processes of fear, such as reconsolidation and behavioral tagging.
详细描述
The study employs healthy participants and includes three experimental sessions, roughly 24 h apart. During the first session, participants undergo context conditioning in virtual reality where the CS+ and CS- are two different rooms. During the second session, half of the participants perform an exploration of a novel virtual environment, and the other half performs a visual attention task. About 60 min later, participants undergo extinction to the context conditioning performed in session 1, again in virtual reality. In session 3, remaining threat responses are measured through a reinstatement procedure, again in virtual reality.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
Participants are never told which manipulation that is expected to affect the threat memory processes.
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Willing and able to provide informed consent and complete study procedures
排除标准
- •Current psychiatric disorder.
- •Current use of psychotropic medication
- •Current use of neurological conditions
结局指标
主要结局
Physiological arousal response during reinstatement.
时间窗: Day 3
Startle responses and skin conductance responses are used as measures of physiological arousal response.
次要结局
- Subjective fear ratings(Day 1, 2 & 3.)
- Subjective discomfort ratings(Day 1, 2 & 3)
- Physiological arousal response during threat conditioning(Day 1)
- Physiological arousal response during extinction(Day 2)