Intraventricular Tissue Plasminogen Activator in the Management of Aneurysmal Subarachnoid Hemorrhage: a Randomized Controlled Pilot Study
试验速览
- 阶段
- 2 期
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Determine rate and variance of ventricular and cisternal clot clearance (with and without TPA).
研究概览
简要总结
The proposed study is to evaluate the acceleration the clearance of intraventricular blood (IVH) and subarachnoid hemorrhage (SAH) following ruptured intracranial aneurysms, thereby ameliorating complications, such as cerebral vasospasm, hydrocephalus and intracranial hypertension.
The primary objectives are:
- Estimate the rate and variance of hematoma clearance following aneurysmal SAH, thereby facilitating sample size determination for a subsequent larger study;
- Assess the feasibility of a randomized controlled trial of intraventricular tissue plasminogen activator (TPA) among patients with SAH (enrollment rate, ability to blind investigators, protocol compliance);
- Confirm the safety of intraventricular TPA.
详细描述
Outcome Measures:
Safety will be assessed through adverse events, hemorrhagic complications and the development of ventriculostomy-related infections.
The volume and clearance of intracranial blood will be determined (in ml) using computerized software, as well as validated semi-quantitative ordinal scales (SAH Sum Score, Modified Graeb Score). The amount of IVH and SAH will be assessed at baseline (day 0), 72 hours after treatment onset, and on post-SAH day 8.
Additional secondary outcomes will include:
- The occurrence of vasospasm, as determined using transcranial Doppler ultrasonography
- The occurrence of radiographic vasospasm, using CT angiography.
- The occurrence of "clinical" (symptomatic) vasospasm
- The rate of catheter-related central nervous system infections
- Levels of cytokines, endothelin and matrix metalloproteases in cerebrospinal fluid (CSF) and plasma
- Levels of fibrin-derived products (FDP), TPA and plasminogen-activator inhibitor in CSF
- Levels of S100β and neuron-specific enolase (NSE) in CSF and serum
- Intracranial pressure
- Volume of CSF drainage
- Extended Glasgow Outcome Scale, modified Rankin scale, EuroQOL at 6 months post-SAH
- Duration that ventriculostomy is required; need for permanent shunt
- Fever burden
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (> 18 years old) with a proven ruptured cerebral aneurysm
- •Aneurysm has been / will be treated with coil embolization
- •EVD has been / will be placed as part of routine care
- •Modified Fisher score is 4 (cisternal blood > 1 mm thick with concomitant IVH)
- •CT scan after EVD placement shows "stability" with no increase in the amount of intracranial blood (Note: there is sometimes layering of blood, especially in the occipital horns of the lateral ventricles, that develops during the first 24-48 hours after a ruptured aneurysm due to circulation of blood in the CSF - this does not necessarily constitute an exclusion criterion).
- •Study drug can be administered within 72 hours of the time of SAH.
排除标准
- •Concern expressed by endovascular neurosurgeon / interventional radiologist that aneurysm has only been incompletely treated / isolated by coil embolization.
- •Patient requires craniotomy and clipping of the culprit aneurysm.
- •CT scan performed post-EVD insertion OR post-coiling shows increase in amount of intracranial blood.
- •Uncorrected coagulation disturbance (INR > 1.5, PTT > 45); correction is permitted (if coagulation disturbance develops during the study, subsequent doses of TPA should simply be withheld until coagulation can be corrected).
- •Uncorrected thrombocytopenia (platelets < 50,000); correction with platelet transfusions is permitted.
- •Involvement in another clinical trial
- •Uncontrolled active internal hemorrhage
- •Known allergy to study drug
- •Patient is pregnant
- •Any other condition the investigator believes would place the subject at risk if included in the study.
研究组 & 干预措施
Placebo
Placebo will be administered every 12 hours for a total five doses. Patients will be followed for a total of 6 months.
干预措施: Placebo (Drug)
tPA (tissue plaminogen activator)
Intraventricular TPA will be administered every 12 hours for a total five doses. Patients will be followed for a total of 6 months.
干预措施: Tissue Plasminogen Activator (Drug)
结局指标
主要结局
Determine rate and variance of ventricular and cisternal clot clearance (with and without TPA).
时间窗: 8 Days post bleed
In order to plan the sample size for a future "proof-of-concept" trial, we need to better define the primary endpoint (the rate of ventricular and cisternal clot clearance, as well as the degree of variance in this rate, both with and without TPA).
次要结局
- Confirm the safety of intraventricular TPA.(6 months)
- Assess feasibility of a future multi-center trial(6 months)