Effectiveness of High-Flow Nasal Cannula (HFNC) Preoxygenation in Obese Patients Undergoing General Anesthesia: A Randomised Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Functional Residual Capacity (FRC) variation
研究概览
简要总结
This study aims to evaluate the effectiveness of the High Flow Nasal Cannula (HFNC) for the preoxygenation of obese patients undergoing a general anesthesia. The HFNC interface is compared to a standard anesthesia FaceMask (FM) preoxygenation with Continuous Positive Airway Pressure (CPAP), the current gold standard procedure for obese induction.
The interest of HFNC preoxygenation is to increase the "safe apnea time" before critical arterial desaturation, useful in the management of difficult airways, especially in subjects with reduced respiratory reserves such as the obese.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Surgery with the need for general anesthesia with muscle relaxation
- •ASA (American Society of Anesthesiologists) physical status score II-III
- •BMI > 35
排除标准
- •Severe respiratory disease (acute respiratory failure, Chronic obstructive pulmonary disease COPD, parenchymal pneumopathies,...)
- •Severe nasal pathology (malformation, stenosis)
- •Criteria or previous difficult intubation
- •BMI > 50
- •Chest circumference > 150cm
- •Implanted electronic device (pacemaker, neurostimulator, ...)
- •Pregnancy
结局指标
主要结局
Functional Residual Capacity (FRC) variation
时间窗: 20 minutes
The difference of FRC, estimated by lung Electrical Impedance Tomography (EIT), during general anesthesia induction (from a base period to the mechanical ventilation).
次要结局
- Time of safe apnea(20 minutes)
- Lowest SpO2(20 minutes)
- Preoxygenation Comfort(6 hours)
研究者
Francesco Ricottilli, MD
Resident, Department of Anesthesiology
Erasme University Hospital