Comparison of Anti-inflammatory Effects of Amlodipine and Levamlodipine in Patients With Hypertension
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 主要终点
- After treatment, the blood pressure control of L-amlodipine group was better than that of amlodipine group
研究概览
简要总结
To investigate the anti-inflammatory effect of amlodipine and levamlodipine in the treatment of hypertension
详细描述
A total of 200 inpatients or outpatients in the Department of cardiovascular medicine of the third people's Hospital of Mianyang City from April 2021 to October 2021, who met the diagnostic criteria of ish2020 international hypertension practice guidelines, were selected and randomly divided into control group and experimental group, with 100 cases in each group. The control group was treated with amlodipine and the experimental group was treated with levoamlodipine. The changes of blood pressure and serum inflammatory factors were observed before and after treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •① In line with the diagnostic criteria of ISH2020 International Guidelines for Practice of Hypertension ② Age >18 years old, gender is not limited, during the treatment did not take other drugs that will affect blood pressure: such as antidepressants, oral contraceptives, Chinese herbal medicine, etc.; Voluntary participation and signing of informed consent, and can complete all the visit plan.
排除标准
- •(1) Those who do not want to take blood tests; (2) Left ventricular ejection fraction < 50%, heart rate <50 beats/min; ③ Acute coronary syndrome (unstable angina pectoris and myocardial infarction); ④ valvular heart disease, congenital heart disease, etc.; Other infectious diseases and malignant tumors; ⑥ Bronchial asthma; ⑦ Abnormal liver function and renal dysfunction (ALT BBB 0 80U/L, CR BBB 1 442mmol/L); Autoimmune diseases or any serious and fatal diseases; ⑨ Receiving lipid-lowering therapy and oral vitamins or antioxidants; They are mentally ill, have no self-awareness, and are unable to express themselves or cooperate with others.
研究组 & 干预措施
Levamlodipine group
Blood pressure lowering therapy with 2.5mg levamlodipine, plus metoprolol succinate
干预措施: Levamlodipine (Drug)
Amlodipine group
To receive 5mg amlodipine to lower blood pressure, plus metoprolol succinate
干预措施: Amlodipine (Drug)
结局指标
主要结局
After treatment, the blood pressure control of L-amlodipine group was better than that of amlodipine group
时间窗: One month after treatment
the serum inflammatory factor level of L-amlodipine group was lower than that of amlodipine group
时间窗: One month after treatment
Serum ATP level can be used to evaluate the anti-inflammatory effect of hypertension drugs
时间窗: One month after treatment
次要结局
未报告次要终点