JPRN-UMIN000014568已完成未知
Effectiveness and safety of simeprevir-basd triple therapy for chronic hepatitis C in multicenter study - Effectiveness and safety of simeprevir-basd triple therapy
The Kyushu Univerisity Liver Disease Study Group0 个研究点目标入组 400 人开始时间: 2014年7月16日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 400
研究概览
简要总结
Simeprevir-based triple therapy have a lower risk of the development of severe anemia than telaprevir-based therapy. ITPA genotype and age are useful for individualizing treatment to reduce the risk of anemia-related adverse effects. Simeprevir-based triple therapy will continue to be a useful treatment option for treatment-naive or prior relapse patients with a favorable IL28B genotype (SVR>90%).
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20years-old 至 85years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •(1) positivity for antibody to human immunodeficiency virus or positivity for hepatitis B surface antigen (2) clinical or biochemical evidence of hepatic decompensation (Child-Pugh B or C, ascites, bleeding varices, or encephalopathy); (3) other causes of liver disease (hemochromatosis, autoimmune hepatitis, or primary biliary cirrhosis) (4) excessive active alcohol consumption (a daily intake of more than 40g of ethanol), drug abuse or severe mental disorder (5) the presence of active cancer at entry (6) experienced treatment with telaprevir
研究者
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