Knowledge and Exploratory Study to Better Understand Face Acne Pathophysiology and Acne Lesion Severity by Multi-omic Approaches, Biometrological Analysis and Consumer Needs

Pierre Fabre Dermo Cosmetique2 个研究点分布在 1 个国家目标入组 50 人开始时间: 2023年10月16日最近更新: 2025年2月24日

适应症

试验速览

阶段: 不适用
状态: 终止
发起方
入组人数: 50
试验地点: 2
主要终点: Cutaneous pH measurement

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Acne vulgaris (acne) is a chronic inflammatory pathology of the pilosebaceous unit. Its prevalence is about 85% of teenagers and is constantly increasing in adults, especially women. Acne is a multifactorial disease involving abnormalities in follicular keratinization, sebum production, skin microbiota and inflammation.

The early stage of acne is characterized by the presence of primary retentional lesions: the open comedones (or blackheads) and closed comedones (or whitehead). These retentional lesions can progress to highly inflammatory lesions: superficial inflammatory lesions (papules and pustules) and in some cases in deep inflammatory lesions (nodules). Finally, acne lesions can lead to the development of superficial post inflammatory erythema or hyperpigmentation, resulting in emotional distress and a poorer quality of life.

Currently, a better understanding of the switch from healthy to acne-prone skin, but also of the transition from retentional lesions to more severe inflammatory lesions, seems essential to propose adapted and specific treatments.

The aim of this study is to better understand acne pathophysiology of the face by a multi-omic approaches, biometrological analysis and consumer needs collection to bring information, in the same study on the local ecosystem of non-lesional areas, retentional lesional areas and inflammatory lesional areas of adult acne prone skin, compared to acne free face.

研究设计

研究类型: Interventional
分配方式: Na
干预模型: Parallel
主要目的: Basic Science
盲法: None

入排标准

年龄范围: 18 Years 至 30 Years（Adult）
性别: All
接受健康志愿者: 是

入选标准

•Criteria related to the population:
•For women of childbearing potential: pregnant or breastfeeding
•Subject having received on face artificial UV exposure, excessive or prolonged exposure to natural sunlight within 4 weeks before the inclusion visit
•Subject with facial hair liable to interfere with the study assessments
•Criteria related to the disease:
•Clinical signs of hormone dysfunction or hyperandrogenism
•Severe form of acne (acne conglobata, acne fulminans or nodulocystic acne) or acneiform eruptions, in the investigator's opinion
•Sunburn on the face due to excessive UV exposure
•Criteria related to skin condition:
•Subject having any other dermatologic condition than acne, or characteristics (like tattoo) on the face liable to interfere with the study assessments
•Specific for control group:
•Subject with significant acne lesions according to investigator assessment
•Subject having any inflammatory face dermatosis
•Criteria related to treatments and/or products:
•Any surgery, chemical or physical treatment on the face in the 12 months before the inclusion visit
•Systemic isotretinoin treatment taken in the 6 months prior before the inclusion visit
•Systemic acne treatment taken in the 3 months before the inclusion visit
•Probiotics taken orally in the month before the inclusion visit
•Topical acne treatment applied to the face in the month before the inclusion visit
•Topical or Systemic Non-Steroidal Anti-Inflammatory (NSAI), corticosteroids, taken or applied to the face in the 2 weeks before the inclusion visit
•Skincare product for acne liable to interfere with the study according to investigator's assessment applied to the face in the 2 weeks before the inclusion visit

排除标准

未提供