Transcranial Magnetic Stimulation, Embodied Cognition and Bulimic Craving
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Motor response time
研究概览
简要总结
Bulimic patients suffering from binge eating or "craving" a pressing need to eat, with a sense of unease and anxiety, relieved by food intake. The phenomenon of craving bulimia may be considered appropriately by using paradigms developed in the framework of embodied cognition theories.
In bulimic, a study with 20 bulimic patients proved an automatic attraction (unconscious) for food in these patients, as measured by reaction time.
Moreover, a therapeutic explored in bulimia (particularly on reducing craving), is repeated transcranial magnetic stimulation (rTMS). Studies have shown that a single session of rTMS to the dorsolateral prefrontal cortex left (DLPFC) reduces significantly the food craving among bulimics, 24 hours after stimulation. But the therapeutic efficacy of TMS on bulimia to more than 24 hours has not yet been demonstrated, and the psycho-cognitive underlying mechanisms have not yet been explored.
详细描述
The exams / treatments of the study include:
- a 20 minute session of rTMS at a frequency of 10 Hz.
- cognitive testing and attention, which will be made on the computer before and 24 hours after the session of rTMS.
Cognitive test consist in , on a computer screen:
- Is first displayed, food and non-food words. The patient must pull a lever to it if the letter A is present in the word and push the lever if the letter A is missing the word.
- Then presents a series of food and non-food words. The patient must pull a lever to it if it deems that the word has a positive meaning and push the lever if it determines that the word has a negative meaning
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •right-handed patient
- •Patients without psychotropic treatment or treatment with a stable and unchanged for over a month.
- •Normal BMI
排除标准
- •Previous history of seizures or epilepsy.
- •Participants with a somatic problem restricted movement or an uncorrected visual acuity problem.
- •History of head trauma, neurological disease or unstabilized serious physical illness.
- •Major Depressive Episode at the time of the study
结局指标
主要结局
Motor response time
时间窗: 24h after rTMS session
time taken to pull or push the lever in cognitive tests (composite measure)
次要结局
未报告次要终点