High-Frequency Repetitive Transcranial Magnetic Stimulation Assists In Smoking Cessation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- number of cigarettes smoked
研究概览
简要总结
Cigarette smoking is a major public health problem causing significant morbidity and mortality. Yet, smoking cessation therapies are often ineffective at helping smokers break their addiction.
The mesolimbic dopaminergic reward system plays a crucial role in mediating the reinforcing effects of nicotine. Recently, acute high frequency repetitive transcranial magnetic stimulation (rTMS) of frontal brain regions has been shown to efficiently modulate the mesolimbic dopamine systems in both animals and humans. For this reason, we investigated whether 10 high-frequency (10Hz) rTMS treatments over the left dorsolateral prefrontal cortex can help people to withdraw smoking in comparison to placebo rTMS.
Smokers seeking to quit are recruited through newspaper advertisements. Participants were randomized to 10 days of either real or placebo high frequency rTMS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Smoking over 20 Cig a day -
排除标准
- •epilepsy, psychiatry history
研究组 & 干预措施
Real high frequency rTMS
The patients will undergo a series of treatments of high frequency rTMS
干预措施: Transcranial Magnetic Stimulation 10Hz (Device)
Sham high frequency rTMS
The patients will receive a series of sham treatments.
干预措施: Magnetic stimulation using a special sham coil (Device)
结局指标
主要结局
number of cigarettes smoked
次要结局
未报告次要终点