Prevalence of Depressive Symptoms and Cognitive Impairment and Their Association With Worse Outcomes in a Cohort of Hospitalized Patients With Chronic Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- In-hospital all-cause mortality
研究概览
简要总结
The goal of this observational study is to learn about the prevalence of depressive symptoms and cognitive impairment and their association with worse outcomes in a cohort of hospitalized patients between the ages of 18 ang 85 years with chronic heart failure. The main question it aims to answer is:
• Does the presence of depressive symptoms and cognitive impairment lead to worse outcomes in a cohort of hospitalized patients with chronic heart failure? Participants who are hospitalized due to exacerbation of chronic heart failure will answer survey questions to assess their cognitive function and depressive symptoms.
详细描述
This is a single-centre, prospective, observational cohort study designed to evaluate the prevalence of depressive symptoms and cognitive impairment and to investigate their association with worse clinical outcomes in hospitalized patients with chronic heart failure (CHF). The study will be conducted at the Department of Cardiology and the Internal Medicine Department's Cardiology Profile of the Lithuanian University of Health Sciences Kaunas Hospital (LSMU Kaunas Hospital), Kaunas, Lithuania, where the majority of Kaunas region patients with CHF are admitted for inpatient care.
CHF is a common clinical syndrome resulting from structural and/or functional cardiac abnormalities, leading to typical symptoms, frequent hospitalizations, reduced quality of life, and high mortality. In addition to somatic burden, patients with CHF frequently experience cognitive impairment and mental health disorders, particularly anxiety and depressive disorders. These conditions are highly prevalent and are associated with poorer self-care, impaired adherence to therapy, diminished quality of life, and worse prognosis. Despite increasing recognition of their importance, depressive symptoms, anxiety, and cognitive impairment remain under-recognized and insufficiently integrated into routine CHF management. Symptom overlap between CHF and mental or cognitive disorders further complicates detection, contributing to underdiagnosis and undertreatment.
To address this gap, the present study will systematically assess depressive symptoms and cognitive function in a consecutively enrolled cohort of hospitalized patients with CHF and will examine how these factors relate to short- and medium-term outcomes.
The main objectives are:
- to determine the prevalence of depressive symptoms in hospitalized patients with CHF;
- to determine the prevalence of cognitive impairment in the same population;
- to evaluate the association between depressive symptoms and worse CHF outcomes;
- to evaluate the association between cognitive impairment and worse CHF outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient hospitalized primarily for CHF exacerbation;
- •clinically stable, able to provide informed consent;
- •do not have severe cognitive impairment that would preclude valid questionnaire administration.
排除标准
- •hospitalization for acute heart failure;
- •total length of hospital stay <96 hours;
- •absence of transthoracic echocardiography (TTE) within the last 12 months and no TTE planned;
- •severe visual impairment preventing completion of the visual part of the Montreal Cognitive Assessment;
- •refusal to participate.
结局指标
主要结局
In-hospital all-cause mortality
时间窗: From enrollment to the end of treatment up to 30 days
Lethal all-cause outcome
In-hospital MACE
时间窗: From enrollment to the end of treatment up to 30 days
In-hospital Major Adverse Cardiovascular Event (including myocardial infarction, stroke, cardiovascular death, and need for revascularization \[like repeat PCI or bypass surgery\])
Number of Participants with chronic heart failure-related rehospitalization
时间窗: 12 months post discharge from the hospital
Subsequent hospitalization due to chronic heart failure exacerbation (decompensation) within 12 months after the index admission to the hospital (enrollment to the study)
次要结局
未报告次要终点
研究者
Andrius Ališauskas, MD
Principal Investigator
Lithuanian University of Health Sciences