An examination of whether measures of brain function and structure in subacute post-stroke aphasia predict language recovery (naming and comprehension) and word retrieval treatment response at 3 months and 6 months post stroke-onset.

Professor David Copland0 个研究点目标入组 115 人开始时间: 2017年3月31日最近更新: 2020年11月2日

试验速览

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•People with aphasia:
•- Single, first, left hemisphere stroke (as confirmed by CT/MRI) and speech and language impairment as identified by a speech pathologist or other relevant medical, nursing or allied health staff
•-Below the aphasia cut-off (93.8 AQ) on the Western Aphasia Battery - Revised (WAB-R) or asphasia (including high level language deficits) as identified by a speech pathologist or other relevant medical, nursing or allied health staff
•- MRI compatibility, and able to complete behavioural battery between 2 and 6 weeks post-stroke
•- Have sufficient vision and hearing to complete the imaging and behavioural tasks
•- Medically stable and able to attend and participate in a therapy program (8 weeks)
•- English as a primary language prior to stroke
•Control Group:
•- healthy older adults matched for age and gender.

•People with aphasia:
•- Any other neurological disease or disorder, mental illness, head trauma, alcoholism, cerebral tumour or abscess.
•- Any metals present in the body or other contraindications for MRI including claustrophobia.
•- Current diagnosis of major clinical depression or other mental health condition that may affect participation.
•- Severe dysarthria or apraxia of speech as determined by a speech pathologist.
•- Severe auditory comprehension deficits as determined by the WAB-R which would preclude following directions for the scan.
•- Substance abuse or dependence in the last 12 months.
•Healthy controls:
•- Any brain/neurological disorder, mental illness, head trauma, alcoholism and cerebral tumour
•- Any contraindications for MRI – claustrophobia or metals in the body e.g., pacemaker, heart valve, dental bridge metal mesh implants/clips/wire sutures, hearing implant etc.

发起方

Professor David Copland