NCT02010307Unknown不适用
Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis
适应症
试验速览
- 阶段
- 不适用
- 发起方
- Polak David
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- flow cytometry
研究概览
简要总结
aggressive periodontitis is an inflammatory disease which damage the teeth supporting structures mostly in young patients. and has genetic basis.
a specific bacteria: Aggregatibacter actinomycetemcomitans (Aa) is associated with this disease, and found to damage leukocytes by using a specific leukotoxin.
in the research the investigators are aiming to find molecular and immunological basis to aggressive periodontitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients in periodontal department
- •diagnosed with chronic/aggressive periodontal disease
- •interested in participating the research
排除标准
- •diagnosed with diabetes, heart disease, immunosuppression, thrombocytopenia, clotting enzyme deficiency.
- •using alcohol, or drugs
- •pregnancy
结局指标
主要结局
flow cytometry
时间窗: 12 hours after blood extraction
the investigators use flow cytometry technique in order to determine the influence of gingival bacteria on the leukocytes, after culturing the two together.
次要结局
- microscopy observation(12 hours after blood extraction)
研究者
Polak David
senior dentist, periodontology department
Hadassah Medical Organization
研究点 (1)
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