Effects of Ramelteon on Sleep and Neurobehavioral Performance in a Simulated Night Shift Preceded by a Sleep Opportunity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 主要终点
- Sleep Efficiency
研究概览
简要总结
Night shift-workers are often advised to take a prophylactic nap prior to starting the shift in order to improve alertness and performance. However, individuals often report difficulty initiating and maintaining sleep at that time of the day secondary to the alerting influence of the near-24 hour circadian rhythm (biological clock). A sleep-promoting medication may improve the quality of an evening nap and subsequent alertness and performance during a night shift. We will use Ramelteon, a melatonin agonist that is FDA approved for insomnia, in order to test the following hypotheses:
- ramelteon, compared with placebo, will significantly increase sleep efficiency during a 2-hour nap;
- sleep inertia, as assessed by neurobehavioral tests and subjective and objective sleepiness assessments will not be significantly increased after ramelteon treatment compared with placebo treatment; and
- neurobehavioral performance, subjective and objective sleepiness, and subjective mood during a simulated 8-hour night shift will be significantly improved when ramelteon is given prior to a prophylactic nap compared to a prophylactic nap with placebo.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged between 18-35 years;
- •Non-smoking for at least 6 months;
- •Healthy (no medical, psychiatric or sleep disorders);
- •No clinically significant deviations from normal in medical history, vital signs, physical examination, blood chemistry and hematology, and ECG;
- •Women of childbearing potential must agree to use an acceptable method of birth control, and must have a negative serum pregnancy test;
- •Body mass index of > 18 or < 30 kg/m∧2;
- •No drugs or medication likely to affect sleep or alertness, as determined by the investigators;
- •Habitual caffeine consumption < 300 mg per day on average;
- •Habitual alcohol consumption < 10 alcoholic units per week on average.
排除标准
- •History of alcohol or substance abuse;
- •Positive result on drugs of abuse screening;
- •Current or past history of sleep disorders, including but not limited to obstructive sleep apnea, or any significant sleep complaint;
- •Psychiatric disorder, including a history of depression or dysthymia (characterized by depressed mood on the majority of days for at least two years);
- •Recent acute or chronic medical disorder, including but not limited to hepatic impairment and severe chronic obstructive pulmonary disease;
- •History of intolerance or hypersensitivity to melatonin or melatonin agonists;
- •Pregnancy or lactation;
- •Shift work;
- •Transmeridian travel (2 or more time zones) in past 2 months;
- •Any other scientific or medical reason, as determined by the PI, such as non-compliance with protocol or intolerance to inpatient study conditions.
研究组 & 干预措施
1
Ramelteon 8 mg will be given once prior to a 2-hour nap
干预措施: Ramelteon (Drug)
2
Placebo will be given once prior to a 2-hour nap
干预措施: placebo (Drug)
结局指标
主要结局
Sleep Efficiency
时间窗: 2 hours
total sleep time/time in bed \* 100% (higher values indicate better outcome)
次要结局
未报告次要终点
研究者
Elizabeth B. Klerman
Associate Professor, Associate Physician
Brigham and Women's Hospital