A Clinic Trail on Nutrition Support Therapy of Patients With Liver Failure
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- Mortality at 30 day
研究概览
简要总结
This study is a Clinical trial to assess the efficacy of nutrition support therapy of patients with liver failure. Patients were randomized to one of 2 groups to receive different nutrition and energy support treatment.
详细描述
Patients with liver failure (defined by APASL) induced by any precipitating factors were randomized to two groups; a treatment group and a control group. Participants in treatment group were provided with a standard hospital diet that provided 25-30 kcal/kg/day . Patients in control group receive diet guide
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male and female patients from 18 to 65 years of age;
- •Patient inclusion criteria: jaundice (serum total bilirubin ≥5 mg/dl) and coagulopathy (INR ≥ 1.5 or prothrombin activity ≥ 40 %), accompanied by ascites and/or encephalopathy within 4 weeks.
排除标准
- •Surgery with in 4 weeks
- •three degree hepatoencephalopathy
- •malignant tumors
- •cardiac failure or respiratory failure
- •liver transplantation within observing period -
研究组 & 干预措施
control group
All study participants were not intervened with diet
a treatment group
All study participants were provided with a standard hospital diet that provided B25-30 kcal/kg/day
干预措施: standard hospital diet (Dietary Supplement)
结局指标
主要结局
Mortality at 30 day
时间窗: 4 weeks
The percentage of death of liver failure patients at 4 weeks
次要结局
- Laboratory variables on fasting blood sugar(3month)
- liver transplant-free survival(3month)
- Laboratory variables on serum biochemistry markers(3month)
研究者
Qin Ning
Director and Chair of Department of Infectious Diseases
Tongji Hospital