Lung Cancer Screening and Tissue Procurement

OBJECTIVES:

Primary

• Classify annual sputum samples cytologically in participants with or without airflow obstruction and a heavy smoking history.
• Correlate sputum cytological atypia (moderate atypia or worse) with lung cancer incidence in these participants.
• Correlate changes in sputum cytology (i.e., changes toward higher grades of atypia) with lung cancer incidence in these participants.

Secondary

• Determine other risk factors for lung cancer (e.g., diet, family history, smoking history, and medications) that may either confound or modify the association between sputum cytology and lung cancer risk in these participants.