NCT03393988Unknown4 期
A Pilot Study for a Prospective, Randomized Controlled Trial of Techniques for Perioperative Analgesia for Live Liver Donors
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Total fentanyl consumption
研究概览
简要总结
This study,will evaluate the efficacy of ultrasound (US)-guided subcostal oblique TAP block together with IV infusion of Dexmedetomidine and fentanyl as a type of multimodal analgesic regimen in comparison with IV fentanyl based analgesia only in live liver donors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesia (ASA) physical status I or II
- •Scheduled as live liver donors
- •J-shaped incision in the supraumblical region
排除标准
- •Patients with a history of psychiatric/neurological illness,
- •Hypertensive patients,
- •Morbidly obese patients,
- •Pregnant and nursing women,
- •Patients with known allergic reaction to any of the study medications,
- •Patients on recent use of sedatives or analgesics,
- •Patients with significant laboratory abnormalities
研究组 & 干预措施
Group F
Active Comparator
Fentanyl infusion (0.5 µg/kg/hr)
干预措施: Fentanyl infusion (Drug)
Group (TAP-Dex)
Active Comparator
Ultrasound guided TAP block and Dexmedetomidine
- Ultrasound guided subcostal oblique TAP block with 0.25 % bupivacaine
- Dexmedetomidine infusion(200 µg in 2 ml diluted in 48 ml of saline)
- Fentanyl infusion (0.5 µg/kg/hr).
干预措施: Fentanyl infusion (Drug)
Group (TAP-Dex)
Active Comparator
Ultrasound guided TAP block and Dexmedetomidine
- Ultrasound guided subcostal oblique TAP block with 0.25 % bupivacaine
- Dexmedetomidine infusion(200 µg in 2 ml diluted in 48 ml of saline)
- Fentanyl infusion (0.5 µg/kg/hr).
干预措施: Ultrasound guided TAP block (Procedure)
Group (TAP-Dex)
Active Comparator
Ultrasound guided TAP block and Dexmedetomidine
- Ultrasound guided subcostal oblique TAP block with 0.25 % bupivacaine
- Dexmedetomidine infusion(200 µg in 2 ml diluted in 48 ml of saline)
- Fentanyl infusion (0.5 µg/kg/hr).
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
Total fentanyl consumption
时间窗: Intraoperative
Total Intravenous fentanyl consumption during the operation
次要结局
- Average sevoflurane concentration(Intraoperative)
- The severity of postoperative nausea and vomiting (PONV)(First 24 hours postoperatively)
- Ramsay sedation score (RSS)(First 24 hours postoperatively)
研究者
Rasha Samir Abd-ElWahab Bondok
Professor
Ain Shams University
研究点 (1)
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