Role of Staphylococcus Aureus on Folliculitis Decalvans. A Comparative Bacteriological Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- presence of Staphylococcus Aureus in cutaneous biopsies (at least one colony)
研究概览
简要总结
The folliculitis decalvans (FD) is an orphan disease , common in consultation specialized on scalp. This disease is currently not curable, responsible for significant for patients. The pathophysiology is poorly understood, Staphylococcus aureus (SA) appears to play a role, never previously studied, and the study will attempt to clarify it.
Controversies in the literature on the pathophysiological hypotheses can be summed up as follows :
FD is it an infectious folliculitis where SA (almost always found on the lesions plays a direct role possibly aided by a lack of local immune protection , or is it a pustular inflammatory unknown cause where the SA has no direct role but is a cofactor or a simple germ superinfection.
Our study has plans to bring new evidence to help decide between these two opposite but not mutually exclusive concepts .
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult (>18 yo)
- •folliculitis decalvans
- •At least 6 months of evolution
- •no antibiotics
- •presence of pustules and crusts
- •Adult (>18 yo)
排除标准
- •immunosuppression
- •pregnancy
结局指标
主要结局
presence of Staphylococcus Aureus in cutaneous biopsies (at least one colony)
时间窗: 1 day
The primary endpoint is the presence of Staphylococcus Aureus in cutaneous biopsies before any therapy and notably antibiotics.
次要结局
- presence of Staphylococcus Aureus in cutaneous biopsies (at least one colony) after treatment(10 weeks)
- presence of Staphylococcus Aureus in nasal swab (at least one colony)(1 day)