Pain and Split-belt Motor Learning in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Learning magnitude
研究概览
简要总结
The purpose of this research is to investigate the impact of acute pain, induced using an experimental pain paradigm of capsaicin paired with heat, on implicit locomotor learning and its retention in older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 55-90 years old
- •Self-identifying as generally medically healthy
- •Able to read, write and speak English
- •Able to provide informed consent and attend all testing sessions
- •Willing to undergo the experimental pain paradigm, if selected
排除标准
- •Resting heart rate < 50 or > 100 bpm
- •Resting blood pressure < 90/60 or > 165/95
- •Any history or current mental health condition, learning/developmental disability or cognitive impairment, including severe untreated ADD/ADHD, severe untreated anxiety, severe untreated depression, autism spectrum disorder, insomnia, mild cognitive impairment, etc. (Mild to moderate treated ADD/ADHD, anxiety, and/or depression are allowed.)
- •Score on the Montreal Cognitive Assessment (MoCA) <23
- •Score on the Generalized Anxiety Disorder-7 Scale ≥ 10
- •Score on the Patient Health Questionnaire-2 ≥ 2 and score on the Patient Health Questionnaire-9 ≥ 10
- •Any current (within last 3 month) or chronic medical conditions, including any musculoskeletal, cardiovascular, pulmonary, metabolic, psychiatric or neurological diagnosis that affects activities of daily living or would confound testing or place the subject at risk by participating, such as a significant cardiovascular condition or event (e.g., heart attack < 3 months ago, uncontrolled atrial fibrillation, uncontrolled angina, congestive heart failure, chronic obstructive pulmonary disorder, or peripheral vascular disease)
- •Any impaired sensation or weakness in either lower extremity
- •History of serious concussion or head injury, defined as a loss of consciousness for > 5 minutes and/or requiring medical treatment, or > 2 concussions over the lifespan
- •Any history of acute or chronic problems with balance, any dizziness, or > 1 fall in the last 12 months
- •Currently or regularly using any analgesic medications, over-the-counter remedies, or any other treatment for the purposes of pain relief (i.e., baby aspirin for heart health is allowed)
- •Any current or chronic pain condition during the last year, located anywhere in the body with an intensity of > 2/10
- •Allergy to capsaicin or hot peppers
- •Any skin lesion, breakage or irritation in the area targeted for the painful stimulus
- •Significant skin sensitivity to soaps/creams/perfumes or to heat
- •Poor circulation in the area targeted for the painful stimulus
- •Prior participation in a split-belt locomotor learning study in the Neuromotor Behavior Lab in the past 2 years
结局指标
主要结局
Learning magnitude
时间窗: End of day 1
Step length asymmetry averaged over the last 25 strides of the practice period on day 1.
Retention magnitude
时间窗: Beginning of day 2.
Step length asymmetry averaged over the first 4 strides of the re-adaptation period on day 2.
Forgetting index
时间窗: End of day 1 and beginning of day 2.
Difference between retention magnitude and learning magnitude.
Forgetting index
时间窗: End of day 1 and beginning of day 2.
Difference between retention magnitude and learning magnitude.
Learning magnitude
时间窗: End of day 1
Step length asymmetry averaged over the last 25 strides of the practice period on day 1.
Retention magnitude
时间窗: Beginning of day 2.
Step length asymmetry averaged over the first 4 strides of the re-adaptation period on day 2.
次要结局
未报告次要终点