NCT06520189尚未招募不适用
Value of F-18 FDG PET/CT for the Prediction of EGFR Mutation in Lung Cancer Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 主要终点
- • Assessment of semi-quantitative F-18 FDG PET/CT as a non-invasive method for prediction of EGFR mutations in lung cancer patients.
研究概览
简要总结
To detect value of F-18FDG PET/CT as a non-invasive method for the prediction of EGFR mutations in lung cancer patients.
详细描述
- Globally, lung cancer cases and deaths are rising. In 2018, GLOBOCAN estimated 2.09 million new cases (11.6% of total cancer cases) and 1.76 million deaths (18.4% of total cancer deaths). It is the most frequent cancer and cause of cancer death in men.
- Epidermal growth factor receptor (EGFR) mutations are the second most common oncogenic driver event in non-small cell lung cancer (NSCLC) and classical activating mutations are well defined as strong predictors for good clinical response to EGFR tyrosine kinase inhibitors (EGFRi).
- Over the last decade, the introduction of tyrosine-kinase inhibitors (TKIs) has showed a remarkable paradigm shift in the treatment of non-small cell lung cancer (NSCLC). However, genetic testing is sometimes unavailable.
- Data from previous studies that have investigated the value of F-18 FDG PET/CT for predicting EGFR status are conflicting.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •NSCLC patients who underwent EGFR mutation testing.
- •All patients ≥ 18 years.
排除标准
- •Time interval between EGFR sampling and PET/CT more than 1 month.
- •Patients had been treated before sampling for the gene alteration analysis
- •Patients with glucose level < 200 mg/dl.
结局指标
主要结局
• Assessment of semi-quantitative F-18 FDG PET/CT as a non-invasive method for prediction of EGFR mutations in lung cancer patients.
时间窗: baseline
detection value of F-18 FDG PET/CT for the prediction of EGFR mutation in lung cancer patients.
次要结局
- • Assessment of the relationship between degree of the tracer uptake and pathology of the lesion.(baseline)
研究者
Walaa Gamal Fathy
Assistant lecturer
Assiut University
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