NCT03482284已完成不适用
Exploratory Study on the Modulation of Endotoxemia and Metabolic Parameters: Role of Macronutrients
Prof. Dr. Ina Bergheim0 个研究点目标入组 12 人开始时间: 2016年5月20日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 主要终点
- Changes in parameters of intestinal barrier function
研究概览
简要总结
The aim of the present study is to determine the effect of monosaccharides on intestinal barrier function in healthy subjects.
详细描述
In the intervention study normal weight participants will receive defined amounts of monosaccharides for several days. Before and after intervention parameters of intestinal barrier function will be assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI <25 kg/m2
- •no kown history of metabolic disorders or fatty liver
排除标准
- •food allergies or intolerances (esp. fructose intolerance and malabsorption)
- •renal insufficiency
- •chronic disease of the gastrointestinal tract
- •taking drugs affecting lipid or glucose metabolism
研究组 & 干预措施
Monosaccharide 1
Experimental
Participants receive standardized meals with a defined amount of monosaccharide 1.
干预措施: Dietary Intervention (Other)
Monosaccharide 2
Experimental
Participants receive standardized meals with a defined amount of monosaccharide 2.
干预措施: Dietary Intervention (Other)
结局指标
主要结局
Changes in parameters of intestinal barrier function
时间窗: 1 week
Changes in endotoxin plasma levels
次要结局
- Changes in blood pressure(1 week)
- Changes in markers for glucose metabolism(1 week)
- Changes in blood lipid levels(1 week)
- Changes in Uric Acid levels(1 week)
研究者
Prof. Dr. Ina Bergheim
Prof. Dr.
University of Vienna
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