NCT03673306已完成不适用
A Multicenter Retrospective Study on the Prognostic Impact of Pregnancy in Women With History of BRCA Mutated Breast Cancer
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 4,732
- 试验地点
- 81
- 主要终点
- Disease-free Survival
研究概览
简要总结
The present study aims at refining the understanding of the effect of pregnancy on breast cancer outcomes in the specific population of BRCA mutated patients with known history of breast cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of invasive breast cancer between January 2000 and December 2020;
- •Breast cancer diagnosis at the age of ≤ 40 years;
- •Known presence of germline BRCA mutation.
排除标准
- •Known BRCA mutation with no diagnosis of invasive breast cancer;
- •Diagnosis of ovarian cancer or other malignancies with no history of invasive breast cancer;
- •Diagnosis of hereditary or familiar invasive breast cancer without BRCA mutation or with BRCA genes not tested;
- •Diagnosis of invasive breast cancer with germline BRCA variants of unknown significance.
结局指标
主要结局
Disease-free Survival
时间窗: 10 years
The primary end points were the cumulative incidence of pregnancy and disease-free survival.
Cumulative Incidence of Pregnancy After Breast Cancer
时间窗: 10 years
The primary end points were the cumulative incidence of pregnancy and disease-free survival.
次要结局
- Breast Cancer-Specific Survival(10 years)
- Overall Survival(10 years)
研究者
研究点 (81)
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