Right Ventricular Strain in Detecting Subclinical Right Ventricular Systolic Dysfunction in Psoriatic Arthritis Patients: Relation to Serum Endostatin Level
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Detecting subclinical right ventricular systolic dysfunction in PsA patients
研究概览
简要总结
The aim is to assess early right ventricular systolic dysfunction in psoriatic arthritis patients using RV strain echocardiography
详细描述
Previous studies evaluated RV strain for detection of subclinical RV affection due to PAH in systemic lupus erythematosus. However , to our knowledge , the study of RV strain and its possible association with serum endostatin to detect subclinical right ventricular systolic dysfunction and its relation to PAH in PsA patient is still a novel. Our aim is to assess early right ventricular systolic dysfunction in psoriatic arthritis patients using RV strain Echocardiography.
To evaluate serum endostatin as an objective biomarker for Pulmonary arterial hypertension.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Psoriatic arthritis patients according to CASPAR criteria
- •Psoriatic arthritis patients without overt cardiovascular symptoms
- •Patients with age between 20 to 50 years of age
排除标准
- •Other systemic autoimmune diseases
- •Patients with a history of known valvular disease, atrial fibrillation or any other arrhythmia , heart failure, ischemic cardiomyopathy severe obstructive pulmonary diseases and metabolic syndrome.
- •Patients with medical disorders as renal, congenital heart diseases, hematological disorders and cancer patients.
- •Patients taking certain drugs that have been confirmed to be risk factors for PAH such as appetite suppressant intake drugs (aminorex, fenfluramine derivatives and benfluorex) and chemotherapeutic agents.
- •Family history of myocardial infarction, cerebrovascular disease or sudden death before the age of 65y in females and 55 y in males.
结局指标
主要结局
Detecting subclinical right ventricular systolic dysfunction in PsA patients
时间窗: Up to 24 months
Detecting subclinical right ventricular systolic dysfunction in PsA using 2D strain transthoracic echo and its relation to serum endostatin level
次要结局
未报告次要终点