Low-carbohydrate Diet, With or Without Exercise, for Improving Postprandial Glucose Control and Vascular Function in Type 2 Diabetes and Prediabetes.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Difference in glycemic control assessed by continuous glucose monitoring in low-carbohydrate, low-carbohydrate plus post-meal walking, and high-carbohydrate low-fat arm.
研究概览
简要总结
Large spikes in blood glucose experienced after meals in people with type 2 diabetes are known to damage blood vessels. Low carbohydrate high fat diets and exercise can improve blood glucose control in people with type 2 diabetes but it is unclear how these two strategies interact to affect blood vessel function and inflammation. We will examine how following a short-term low carbohydrate high fat diet (4 days) with or without post-meal walking impacts markers of blood vessel function and inflammation. We will also examine how a single low carbohydrate high fat meal, with or without post-meal walking, impacts blood glucose control and blood vessel function. Findings will help determine the best lifestyle approach for improving cardiovascular health in type 2 diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with type 2 diabetes (at least 6 months ago)
- •Aged 40-75
- •Engaging in 2 or less moderate-to-vigorous exercise bouts per week in the last 3 months
- •Ability to understand and communicate in English to interact with the personal trainer
排除标准
- •Diagnosed coronary artery disease
- •Any contraindications to exercise (e.g., musculoskeletal injury)
- •Prior history of cardio- or cerebrovascular disease or myocardial infarction
- •Hypertension that is not controlled by medication (systolic blood pressure (BP) >160 mmHg and/or diastolic BP >99 mmHg)
- •Change in diabetes medications in the previous 6 months
- •Diagnosed with peripheral neuropathy
- •Taking exogenous insulin
研究组 & 干预措施
Low-carbohydrate diet with post-meal walking
干预措施: Low-carbohydrate diet (Behavioral)
Low-carbohydrate diet with post-meal walking
干预措施: Low-carbohydrate diet with post-meal walking (Behavioral)
High-carbohydrate diet
干预措施: High-carbohydrate diet (Behavioral)
Low-carbohydrate diet
干预措施: Low-carbohydrate diet (Behavioral)
结局指标
主要结局
Difference in glycemic control assessed by continuous glucose monitoring in low-carbohydrate, low-carbohydrate plus post-meal walking, and high-carbohydrate low-fat arm.
时间窗: 4-day average glucose levels assessed in each arm.
次要结局
- Change from baseline in flow mediated dilation of brachial artery after 4 days of intervention.(Fasting measurements taken on day 1 and day 5.)
- Change from baseline in circulating inflammatory cytokines after 4 days of intervention.(Fasting measurements taken on day 1 and day 5.)
- Change from baseline in toll-like receptors 2 and 4 expression on white blood cells after 4 days of intervention.(Fasting measurements taken on day 1 and day 5.)
研究者
Jonathan Little
Assistant Professor
University of British Columbia