Safety and Efficacy of Venetoclax in Idiopathic Pulmonary Fibrosis
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 3
- 试验地点
- 2
- 主要终点
- Number of participants with treatment-related adverse events as assessed by measuring liver function.
研究概览
简要总结
Based on preclinical data, investigators hypothesize that apoptosis resistance in monocyte-derived macrophages (MDMs) have a decisive role in the development of idiopathic pulmonary fibrosis (IPF). Specifically, macrophages from subjects with IPF have increased expression of Bcl-2 in mitochondria. In preclinical models of IPF, a conditional deletion of Bcl-2 in MDMs reverses established fibrosis by inducing apoptosis. Additional evidence to suggest that Bcl-2 expression in MDM mitochondria is a therapeutic target for IPF as administration of the Bcl-2 inhibitor, ABT-199 (Venetoclax), showed marked efficacy in preclinical models of IPF by inducing apoptosis of MDMs and reversing established fibrosis. ABT-199 is an orally available mimetic of the BH3 domain of Bcl-2, which is the domain the anchors Bcl-2 in the mitochondria to inhibit apoptosis. ABT-199 has shown therapeutic efficacy and good safety and tolerability in patients with chronic lymphocytic leukemia. Investigators anticipate that treatment with ABT-199 could result in significant benefit for IPF patients that have a life expectancy of 3-5 years. As there is no curative therapy for IPF, this clinical trial has the potential to substantially alter treatment approaches in patients with IPF.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 40-85 years old, male and female.
- •A diagnosis of IPF that fulfills current ATS/ERS Consensus Criteria (1).
- •IPF duration <5 years, based on the date of definitive diagnosis.
- •Ability and willingness to give informed consent and adhere to study requirements.
- •Forced Vital Capacity (FVC) > 50% predicted values.
排除标准
- •Diagnosis of major comorbidities expected to interfere with study participation.
- •History of malignancy within the last 5 years, excluding basal or squamous cell skin cancer.
- •The occurrence of any acute infection requiring systemic antibiotic therapy within 2 weeks prior to Screening (Visit 1).
- •Treatment for >14 days within the preceding month with >20 mg. prednisone (or equivalent) or any treatment during the last month with a cellular immunosuppressant (e.g., cyclophosphamide, methotrexate, calcineurin inhibitors, azathioprine, etc.), given increased risks of opportunistic infections.
- •Concurrent participation in other experimental trials.
- •Fertile women who do not agree to abstinence or an effective form of contraception (as approved by the investigator), or who are breast feeding, for 4 weeks before randomization until 90 days after the last administration of study medication (or placebo).
- •Men who are not surgically sterile and do not agree to remain abstinent from heterosexual intercourse or use effective contraception (as approved by the investigator), and refrain from donating sperm, from the time of giving informed consent until 90 days after the last administration of study medication (or placebo).
- •Subjects with known hypersensitivity to capsule "bulking" agents.
- •A history of bone marrow disorder including aplastic anemia, or marked anemia defined as hemoglobin < 10.0 g/dL (or 6.2 mmol/L).
- •Severe cardiovascular disease, defined as any of the following within the preceding 12 weeks: acute myocardial infarction or unstable angina, a coronary revascularization procedure, congestive heart failure (NYHA Class III or IV), or stroke, including a transient ischemic attack.
- •Evidence of cardiac conducting abnormalities, defined as second- or third-degree AV block not successfully treated with a pacemaker, or a personal or family history of long QT syndrome (QTc interval >450 msec for males or 470 msec for females).
- •End-stage renal disease requiring dialysis.
- •Undergoing transplantation evaluation or listed with the United Network for Organ Sharing (UNOS) as a lung transplantation candidate at the time of enrollment in this trial.
- •Liver function tests (transaminases, alkaline phosphatase, direct and total bilirubin) >2x upper limit of normal values.
- •Systemically administered potent CYP3A4 inhibitors or inducers are prohibited during the 24-week treatment period.
- •Inhibitors include: pirfenidone, boceprevir, cobicistat, conivaptan, ritonavir, itraconazole, ketoconazole, telaprevir, troleandomycin, voriconazole, clarithromycin, diltiazem, idelalisib, nefazodone, nelfinavir.
- •Inducers include: carbamazepine, enzalutamide, mitotane, phenytoin, rifampin.
研究组 & 干预措施
treatment
Venetoclax 100 mg daily for 3 weeks
干预措施: Venetoclax (Drug)
结局指标
主要结局
Number of participants with treatment-related adverse events as assessed by measuring liver function.
时间窗: 3 weeks
complete metabolic panel
Number of participants with treatment-related adverse events as assessed by measuring blood counts.
时间窗: 3 weeks
complete blood count
次要结局
- Percentage of monocyte-derived macrophages that undergoing apoptosis.(3 weeks)
研究者
A. Brent Carter, MD
Professor
University of Alabama at Birmingham