Patients with rheumatoid arthritis and synovitis treated with ultrasound guided intraarticular or intramuscular glucocorticoid injection - A randomised, double-blind, controlled study (Panguian)

Videncenter for Reumatologi og Rygsygdomme, Rigshospitalet0 个研究点目标入组 100 人开始时间: 2017年9月12日最近更新: 2024年2月26日

适应症

试验速览

暂无简介。

•Treatment demanding synovitis in up to 4 joints, defined as clinical assessed swollen joint and US grey scale og Doppler score =1, in following joints: interphalangeal(IP)-, proximal interphalangeal (PIP)-, metacarpophalangeal(MCP)-, wrist- (radiocarpal-intercarpal and/or ulnacarpal), ankle- and metatarsophalangeal(MTP).
•Rheumatoid arthritis according to ACR/EULAR 2010 criteria
•Above 18 years of age
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 80
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range 20

•Start of Disease-modifying anti-rheumatic drugs (DMARDs) / biological treatment within the last 12 weeks
•Change of DMARDs treatment within the last 6 weeks.
•Change of glucocorticoid treatment within the last 6 weeks.
•Start of Non-Steroidal Anti-Inflammatory Drugs (NSAID) treatment within the last 10 days.
•Chronic synovitis in the same IP-, PIP-, MCP-, wrist-, ankle- and MTP 2-5 joints, is defined as either severe destructive erosions, assessed by previously x-rays or persistent synovitis (6 months) despite >1 local joint injection with glucocorticoid according to DANBIO or journal registrations.
•Treatment demanding synovitis in more than 4 joints, defined as clinical assessed swollen using a 44 joint assessment.
•Lack of ability to understand the information given about the study.
•Recent operation in hands or feet (12 month).
•Allergy to betamethasone.
•Systemic fungal infection
•Positive urine HCG among women in the age of fertility.

发起方

Videncenter for Reumatologi og Rygsygdomme, Rigshospitalet