Molecular Predictors of Lung Cancer Behavior: Controls
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 37
- 试验地点
- 3
- 主要终点
- Collection of biological specimens to use as controls in the study of lung cancer progression
研究概览
简要总结
RATIONALE: Studying samples of blood, urine, sputum, mouth cells, and bronchial tissue from healthy participants in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about the development of cancer.
PURPOSE: This laboratory study is looking for molecular markers in predicting lung cancer development using tissue samples from healthy participants.
详细描述
OBJECTIVES:
- To obtain biological specimens from healthy participants with no known risk of lung cancer to use as controls in the study of lung cancer progression.
- To identify new molecular abnormalities specific to the development of squamous cell carcinoma of the lung.
OUTLINE: Serum, urine, sputum, and buccal cell samples are collected. Patients also undergo bronchoscopy for collection of bronchial tissue and bronchial brush samples. The samples are used for genomic and proteomic studies to identify new molecular abnormalities specific to the development of lung cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Collection of biological specimens to use as controls in the study of lung cancer progression
时间窗: Off study date, up to one year
Specimens are collected from healthy participants with no known risk of lung cancer
次要结局
- Selection of important genes/proteins differentially expressed between study groups (e.g., normal vs low-grade vs high-grade vs invasive) and between normal smokers vs normal non-smokers(off-study date, up to one year)
- Identification of new molecular abnormalities specific to the development of squamous cell carcinoma of the lung(off-study date, up to one year)
研究者
Pierre P. Massion, MD
Associate Professor of Medicine (Allergy, Pulmonary & Critical Care) and Cancer Biology; Pulmonary and Critical Care Medicine Doctor
Vanderbilt-Ingram Cancer Center