Study of Oxidized Albumin in Liver Transplant Patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 10
- 主要终点
- Albumin quality
研究概览
简要总结
The overall goal is to describe the oxidation state of albumin before, during and after liver transplantation. This is a pilot observational study in which the oxidative state in 10 patients undergoing liver transplantation will be described. Samples for analysing the oxidation state of albumin, general oxidative damage and anti-oxidant state, the activation of the complement system and factors involved in coagulation will be obtained before transplantation, before and after reperfusion of the portal vein and on postop days 1, 2 and about 30.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients on waiting list for liver transplantation
排除标准
- 未提供
结局指标
主要结局
Albumin quality
时间窗: Before transplantation, before and after reperfusion of the portal vein and on postop days 1, 2 and about 30.
Describe potential qualitative changes in albumin during the liver transplantation procedure. Non-oxidised, single oxidised and double oxidised albumin will be analysed by HPLC.
次要结局
- Oxidative stress in relation to albumin quality(Before transplantation, before and after reperfusion of the portal vein and on postop days 1, 2 and about 30.)
- Effect of clinical factors on albumin quality before transplantation(Before transplantation.)
- Graft outcome in relation to albumin quality(At days 1, 2 and about 30 days after transplantation)
- Anti-oxidant capacity in relation to albumin quality(Before transplantation, before and after reperfusion of the portal vein and on postop days 1, 2 and about 30.)
- Effect of clinical factors on albumin quality after transplantation(On postop days 1, 2 and about 30.)
- Complement system(Before transplantation, before and after reperfusion of the portal vein and on postop days 1, 2 and about 30.)
- Coagulation(Before transplantation, before and after reperfusion of the portal vein and on postop days 1, 2 and about 30.)
- Binding capacity(Before transplantation, before and after reperfusion of the portal vein and on postop days 1, 2 and about 30.)