Impact of Hypobaric Flight Simulation on Walking Endurance in COPD Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 35
- 试验地点
- 2
- 主要终点
- Change in six minute walking distance measured in meters
研究概览
简要总结
Aim of this study was to evaluate the hypoxic response during hypobaric flight simulation in normal individuals as well as in normocapnic and hypercapnic COPD patients as well as to evaluate the impact of a flight simulation on walking endurance in these patients.
详细描述
Background and aim:
Commercial aircrafts have their altitude compensation adjusted to 2500 meter above sea level which corresponds to a pressure difference of about 270 hPa. This causes a reduction of the partial pressure of oxygen during the flight. Patients with lung disease are especially challenged by large walking distances within airports and during their journey. The objective of our study is to evaluate the impact of a simulated flight under hyperbaric conditions on walking endurance in healthy individuals as well as in COPD Patients with and without hypercapnia.
Method:
Healthy individuals as well as COPD patients were assessed pre-flight with the following measurements:
- Arterial blood gas analysis
- Lung function test
- Lung diffusion test
- Hemoglobin level
- Six minute walking distance
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •No lung disease
- •COPD without hypercapnea
- •COPD with hypercapnea
排除标准
- •Claustrophobia
- •Renal insufficiency
- •Heart failure (ejection fraction < 45 %)
研究组 & 干预措施
COPD normocapnic
three hour flight simulation
干预措施: Environmental (Other)
COPD hypercapnic
three hour flight simulation
干预措施: Environmental (Other)
healthy subjects
three hour flight simulation
干预措施: Environmental (Other)
结局指标
主要结局
Change in six minute walking distance measured in meters
时间窗: 30 Minutes before and after a 3 hour simulated flight (Time point - 30 and + 210 minutes)
difference between pre- and post-flight walking distance
次要结局
- minimal Oxygen saturation measured by pulse oxymetry in %(measurement completed at 180 minutes)
研究者
Dominic Dellweg, M.D.
PD Dr. med
Krankenhaus Kloster Grafschaft