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临床试验/NCT06561282
NCT06561282已完成不适用

The Predictive Role of Glucose/Potassium Ratio for Mortality in Patients With Major Burn Trauma

Konya Meram State Hospital1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2022年5月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
200
试验地点
1
主要终点
Glucose-to-potassium ratio

研究概览

简要总结

The aim of this observational study is to investigate the role of the glucose-potassium ratio in predicting mortality in patients with major burn trauma.

The main question it aims to answer is: Can the glucose-potassium ratio predict mortality in major burn patients? The glucose-to-potassium ratios of major burn patients at the time of initial hospitalization will be determined, and their relationship with mortality will be analyzed.

详细描述

Major burns, especially electrical burns, facial burns, inhalation burns, burns with large burn surface areas, and deep burns, have a high mortality risk. Early detection of this risk may be critical to reducing mortality rates. For this reason, trauma centers are working on rapid and effective prognostic markers. In trauma and stress situations, glucose levels rise while potassium levels fall due to increased catecholamines. The literature reports that hyperglycemia, also known as the glucose-potassium ratio, can rapidly and effectively predict morbidity and mortality in patients suffering from subarachnoid hemorrhage, pulmonary embolism, traumatic brain injury, or blunt abdominal trauma. Many publications show that increased glucose is associated with mortality and morbidity in critical illnesses and trauma. The isolated glucose-potassium ratio has a higher predictive ability for mortality and morbidity compared to glucose and potassium levels. In this study, investigators aimed to examine the prognostic value of the glucose-to-potassium ratio in participants with major burn trauma.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

性别
All
接受健康志愿者

入选标准

  • All burns >40% of total body surface area (2nd degree or deeper)
  • Burns with inhalation injury
  • Burns >20% of total body surface area 3nd degree or deeper

排除标准

  • First degree burns
  • Patients have more than 24 hours since the onset of burn trauma
  • Patients with diabetes mellitus
  • Patients with chronic renal failure
  • Patients taking potassium-modifying medication
  • Patients with missing data

结局指标

主要结局

Glucose-to-potassium ratio

时间窗: 2 days

The glucose-to-potassium ratio is calculated by dividing the participants' glucose values when they first apply to the hospital by their potassium values.

次要结局

  • Burn infection rate(2 days)
  • Mean percent of total body surface area burned(2 days)
  • Mortality rate(2 days)
  • Female/Male ratio(2 days)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Alpaslan Şahin

Principal investigator

Konya Meram State Hospital

研究点 (1)

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