The Study About the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 670
- 试验地点
- 1
- 主要终点
- The most suitable re-eradication time
研究概览
简要总结
The patients who accepted the quadruple eradication program of the helicobacter pylori but failed to eradicate helicobacter pylori will be assessed the most suitable re-eradication time of helicobacter pylori.
详细描述
Helicobacter pylori (HP) infection is a common global infectious disease, which is an important cause of chronic gastritis, peptic ulcer and gastric cancer. At present, due to the non-standard Helicobacter pylori eradication program in clinical work, poor patient compliance and other reasons, the phenomenon of HP eradication treatment failure is more and more common. However, there is still no conclusion on the most appropriate time for remedial treatment inpatients with Hp eradication failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 18-70 with H. pylori infection.
- •Patients with previous Helicobacter pylori eradication.
排除标准
- •Patients treated with H2-receptor antagonist, PPI, bismuth and antibioticsin the previous 4 weeks.
- •Patients with gastrectomy, acute GI bleeding and advanced gastric cancer.
- •Patients with known or suspected allergy to study medications.
- •Currently pregnant or lactating.
- •Inability to provide informed consent and other situations that couldinterfere with the examination or therapeutic protocol.
研究组 & 干预措施
Amoxicillin-Levofloxacin-containing quadruple group
Patients in amoxicillin-Levofloxacin-containing quadruple group will receive esomeprazole (Nexium) 40mg po bid(or vonoprazan fumarate 20mg po bid), amoxicillin1000mg po bid, bismuth potassium citrate(Lizhudele) 220mg po bid, and levofloxacin 500mg po qd for 14d.
干预措施: Amoxicillin,Levofloxacin (Drug)
Amoxicillin-Furazolidone-containing quadruple group
Patients in amoxicillin-furazolidone-containing quadruple group will receive esomeprazole (Nexium) 40mg po bid(or vonoprazan fumarate 20mg po bid), amoxicillin1000mg po bid, bismuth potassium citrate(Lizhudele) 220mg po bid, and furazolidone (Liteling) 100mg po bid for 14d.
干预措施: Amoxicillin,Furazolidone (Drug)
Tetracycline-Furazolidone-containing quadruple group
Patients in tetracycline-furazolidone-containing quadruple group will receive esomeprazole (Nexium) 40mg po bid(or vonoprazan fumarate 20mg po bid), tetracycline 500 mg po qid, bismuth potassium citrate(Lizhudele) 220mg po bid, and furazolidone (Liteling) 100mg po bid for 14d.
干预措施: Tetracycline,Furazolidone (Drug)
结局指标
主要结局
The most suitable re-eradication time
时间窗: 6 months
The most suitable re-eradication time（The unit is month） will be assessed by paired comparison method .
次要结局
- Eradication rates in three groups(6months)
研究者
Xiuli Zuo
Professor, Director of gastroenterology department of Qilu hospita
Shandong University