GWAS Research of Lung Cancer by Department of Epidemiology and Biostatistics in Tianjin Medical University Cancer Institute and Hospital
试验速览
- 阶段
- 不适用
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia
研究概览
简要总结
To study the association of Genetic Polymorphisms with Lung Cancer Risk in Tianjin Population.
详细描述
Eligibility criteria:
- nonsmoker
- female
- age between 35 and 80
- no other types of tumors history
- frequency-matched cases and controls on gender and age
Outcome measures:
- OR(odds ratio)
- RR(risk ratio)
- CI(confidence interval)
- SAS software
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 35 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Non-small cell lung cancer
- •Age from 35 to 80 years old
- •Non-smokers
- •Frequency-matched on age and gender
排除标准
- •Previous medical history of cancer
- •Previous radiotherapy
- •Previous chemotherapy
结局指标
主要结局
Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia
时间窗: 2011-12
A GWAS reported a novel association between the TP63 locus and risk of lung adenocarcinoma; however, this association did not achieve genome-wide significance among never-smoking males or females. We genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 500 never-smoking female lung cancer cases and 500 never-smoking female controls from China. Genetic variation in rs10937405 was associated with lung adenocarcinoma. Our findings provide strong evidence that genetic variation in TP63 is associated with risk of lung adenocarcinoma among non-smoking females.
次要结局
未报告次要终点