Diagnosing Deep-vein Thrombosis Early in Critically Ill Patients (DETECT) Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,800
- 试验地点
- 2
- 主要终点
- 90-day mortality
研究概览
简要总结
The DETECT randomized controlled trial addresses the question of whether surveillance ultrasound in critically ill patients by facilitating DVT detection reduces the incidence of PE and lowers all-cause 90-day mortality. The primary outcome is 90-day all-cause mortality.
详细描述
This is an open-label multicenter multinational randomized-controlled trial. All patients admitted to ICU will be screened within the first 48 hours of ICU admission for eligibility. Subjects who meet all criteria for enrollment will be randomized via a password-protected, secure website using a variable-size block concealed computer-generated randomization procedure. Patients will be allocated to twice weekly bilateral lower limb ultrasound or standard care (control) in a 1:1 ratio.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
90-day mortality
时间窗: 90 days
Mortality 90 days post randomization
次要结局
- Proximal DVT(From randomization date to day 28 or ICU discharge whichever comes first)
- Pulmonary Embolism(From randomization date and throughout hospital stay up to day 28)
- Clinically important bleeding(From randomization date and throughout hospital stay up to day 90)