NCT03438981已完成不适用
Impact op Capillary Leak and Hypoalbuminemia on PK/PD of Ceftriaxone in Critically Ill Patients With Overwhelming Pneumonia
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Risk factors for target non attainment
研究概览
简要总结
WP2.1. PK/PD target attainment Plasma exposure ELF exposure WP2.2. Predictive dosing algorithm WP2.3. ECMO subset
详细描述
First, the investigators will document exposure to ceftriaxone in plasma and epithelial lining fluid.
Second, the investigators will try to identify risk factors for not attaining PK/PD target. Based on significant predictors for target non attainment a predictive dosing algorithm will be constructed.
Finally in a small subset of ECMO patients PK exposure will be explored.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pneumonia
- •Admitted to an ICU ward
- •Treated with ceftriaxone
排除标准
- •Pregnancy
- •DNR code 2-3
- •Renal replacement therapy
结局指标
主要结局
Risk factors for target non attainment
时间窗: on day of sampling
risk factors will be assessed by comparing patients who attain target vs. those who don't
次要结局
未报告次要终点
研究者
Matthias Gijsen
PharmD
Universitaire Ziekenhuizen KU Leuven
研究点 (1)
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