The Levels of Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Gingival Crevicular Fluid in Periodontal Disease and Health
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 75
- 主要终点
- Advanced oxidation protein product (nmol)
研究概览
简要总结
This study investigates the levels of advanced oxidation protein product and monocyte chemoattractant protein-1 in gingival crevicular fluid in periodontal disease and health. 25 participants with chronic periodontitis, 25 participants with gingivitis and 25 periodontally healthy subjects are included into this study. In each participant, four sites are identified for gingival crevicular fluid samples.
详细描述
Oxidative stress is the disequilibrium between the formation of free radicals and antioxidant defense mechanisms via damaging cellular macromolecules (DNA, protein, lipid, etc..) which are susceptible to oxidative damage.
Advanced oxidation protein product is identified as a new marker of protein oxidation.
Monocyte chemoattractant protein-1 is a major chemoattractant for lymphocytes, monocytes and macrophages.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 66 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of chronic periodontitis and gingivitis
排除标准
- •Systemic illnesses
- •Any medications known to affect the periodontium
- •Pregnancy and lactation
结局指标
主要结局
Advanced oxidation protein product (nmol)
时间窗: Before periodontal treatment
次要结局
- The probing depth (mm), clinical attachment level (mm), plaque index scores (0-3) and gingival index scores (0-3)(Before periodontal treatment)
- Monocyte chemoattractant protein-1(pg)(Before periodontal treatment)
研究者
Meltem Karsiyaka Hendek
Corresponding author, Clinical Research
Kırıkkale University