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临床试验/NCT07739069
NCT07739069尚未招募不适用

ACTION OBSERVATION VERSUS MIRROR THERAPY ON UPPER EXTREMITY FUNCTIONS IN CHILDREN WITH SPASTIC HEMIPLEGIC CEREBRAL PALSY

Cairo University1 个研究点 分布在 1 个国家目标入组 36 人开始时间: 2026年8月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
36
试验地点
1
主要终点
gross manual dexterity

研究概览

简要总结

The goal of this clinical trial is to compare the effects of Action Observation therapy and Mirror therapy on hand grip strength and upper extremity function in children with hemiplegic cerebral palsy.

Participants will be randomly assigned into two study groups of equal numbers:

A group will receive traditional physical therapy program followed by mirror therapy protocol 3 times/ week for 12 weeks.

Another group will receive the same traditional physical therapy program in addition exercises using action observation therapy, 3 times/week for 12 weeks.

Then, the effect of both treatments will be compared between the two groups.

详细描述

Hemiplegia is one of the most common movement disorders among children. It occurs in approximately 2.11 out of every 1000 live births. In hemiplegia, one side of the body is affected and the upper limb is usually more affected than the lower limb. Children with hemiplegic CP typically present with impaired selective motor control in the wrist, hand, and fingers. Common deformities include elbow and wrist flexion, thumb-in-palm deformity, and forearm pronation, which reduce the ability to reach, grasp, release, and manipulate objects. Many children compensate by relying on their non-affected hand, leading to developmental disregard of the weaker arm. Impaired upper limb (UL) function affects independence, participation, and quality of life and require effective rehabilitation. Innovative rehabilitation methods that harness neuroplasticity, such as Mirror Therapy (MT) and Action Observation Therapy (AOT), have been increasingly investigated. Both approaches are based on the activation of the mirror neuron system, which plays a key role in motor learning and motor recovery. Mirror Therapy, which is based on visual stimulation from the movements of unaffected limbs, has shown promising results for sensory and upper extremity motor performance of children with hemiplegic CP. Similarly, AOT, which involves observation of purposeful actions with the intention to imitate and then performing those actions, had a significant improvement on grip power, hand function, activities, and participation in activity of daily living in hemiplegic CP children. However, despite the evidence supporting both interventions individually, there is limited research directly comparing their relative effectiveness. Thus, a comparison of MT and AOT is important for a number of reasons. First, it could help clinicians prioritize therapy choices by clarifying whether one intervention results in better improvements in motor outcomes. Second, it will help develop a more sophisticated understanding of how to best utilize various mirror neuron system engagement modalities for pediatric neuro-rehabilitation. Findings may also help create accessible, affordable, and interesting treatment plans that can be incorporated into home-based rehabilitation programs and clinical settings, ultimately enhancing the lives of kids with cerebral palsy and their families.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
5 Years 至 10 Years(Child)
性别
All
接受健康志愿者

入选标准

  • 1- Children diagnosed with spastic hemiplegic CP. 2- Their ages between 5-10 years. 3- Lack of use of the affected upper limb. 4- They will be at level II-III of the Manual Ability Classification System (MACS) 5- The will be at level I-II in the Gross Motor Function Classification System (GMFCS) 6- They will be graded 1 to 1+ in the affected U.L. on Modified Ashworth's Scale 7- The children should be capable of understanding and following instructions.

排除标准

  • The children will be excluded if they have one of the following:
  • Children with fixed contracture in the affected U.L.
  • Injection of botulinum toxin into the upper limb muscles during the previous 6 months.
  • Visual or Auditory disorders.
  • Upper limb surgery in the last one year.

结局指标

主要结局

gross manual dexterity

时间窗: After 12 Weeks

Hand dexterity will be assessed using the Box and Block Test by recording the number of blocks transferred from one compartment to the other within 60 seconds.

次要结局

  • Spontaneous Functional Analysis (SFA) of the Shriners Hospital Upper Extremity Evaluation (SHUEE)(After 12 weeks)
  • Grip strength assessed using a hand dynamometer(After 12 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Nihal Emad

Teaching Assistant

Cairo University

研究点 (1)

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