QT prolongation and relation to severity in cirrhotics

Title QT prolongation and relation to severity in cirrhosis

Study type Retrospective study

Aim To evaluate the relationship between QT prolongation and Child Turcotte Pugh score in patients with cirrhosis

Rationale QT prolongation is common in cirrhosis with a reported prevalence of 30 to 70 percent QT interval increases with worsening Child Pugh class Prolonged QT is associated with ventricular arrhythmias sudden cardiac death and reduced survival Since ECG is routinely performed QT interval may serve as a simple non invasive and cost effective marker of disease severity

Methods Sample size 200 patients Departments involved Gastroenterology Hepatology and Cardiology Study duration 12 months Inclusion criteria Age more than 18 years diagnosed cirrhosis Exclusion criteria Known cardiomyopathy electrolyte abnormalities drugs affecting QT interval Procedure Routine ECG QT corrected using Bazett formula Correlation of QT with Child Pugh score Statistical analysis Descriptive and analytical statistics using SPSS Binary logistic regression

Outcomes Primary outcome Relationship between QT prolongation and severity of cirrhosis Secondary outcome Use of QT prolongation for risk stratification and management

Ethics and risk Minimal risk Written informed consent Confidentiality maintained

Budget 20000 rupees for ECG expenses