Study of Placental Inflammation in Gestational Diabetes: the Role of the Inflammosome NLRP3 and the Scavenger Receptor of Inflammatory Chemokines D6
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Placental inflammation
研究概览
简要总结
The aim of this study is to investigate the placental inflammation in women with gestational diabetes mellitus, in particular the role of inflammasome NLRP3 and the chemokine scavenger decoy receptor D6
详细描述
The aim of this study is to investigate systemic and placental inflammation in women with gestational diabetes mellitus, in particular the role of inflammasome NLRP3 and the chemokine scavenger decoy receptor D6, compared to women with uncomplicated pregnancy
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women with gestational diabetes mellitus
- •Women with uncomplicated pregnancy
- •Age >18 years
- •Singleton pregnancy
排除标准
- •Age < 18 years
- •Infections (HIV,HCV)
- •Multiple pregnancy
研究组 & 干预措施
Women with gestational diabetes mellitus
Blood and placenta sampling will be obtained from cases= women with gestational diabetes mellitus
干预措施: Blood samples for inflammatory markers (Other)
Women with gestational diabetes mellitus
Blood and placenta sampling will be obtained from cases= women with gestational diabetes mellitus
干预措施: Placental Extract (Other)
Healthy women with uncomplicated pregnancy
Blood and placenta sampling will be obtained from controls= women with uncomplicated pregnancy
干预措施: Blood samples for inflammatory markers (Other)
Healthy women with uncomplicated pregnancy
Blood and placenta sampling will be obtained from controls= women with uncomplicated pregnancy
干预措施: Placental Extract (Other)
结局指标
主要结局
Placental inflammation
时间窗: At delivery/birth
Analysis of protein expression of inflammasome NLRP3 and D6 scavenger receptor in placental tissue.
次要结局
未报告次要终点